Surgical Referral for Colorectal Liver Metastases

A Population-Based Survey

Robert W. Krell, Bradley N Reames, Samantha Hendren, Timothy L. Frankel, Timothy M. Pawlik, Mathew Chung, David Kwon, Sandra L. Wong

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Surgical resection is underutilized for patients with colorectal liver metastases (CLM). Although the causes of underutilization are poorly understood, provider attitudes towards surgical referral may be contributory. We sought to understand medical oncologists’ perspectives on referral for CLM. Methods: Medical oncologists who treat colorectal cancer in the US state of Michigan were surveyed. We characterized respondents’ attitudes regarding clinical and tumor-related contraindications to liver resection for CLM, as well as referral and treatment preferences using case-based scenarios. We then evaluated practice characteristics and treatment preferences between physicians. Results: A total of 112 eligible responses were received (46 % response rate). Nearly 40 % of respondents reported having no liver surgeons in their practice area. Commonly perceived contraindications to liver resection included extrahepatic disease (80.3 %), poor performance status (77.7 %), the presence of >4 metastases (62.5 %), bilobar metastases (43.8 %), and metastasis size >5 cm (40.2 %). Compared with high-referring physicians, low-referring physicians were just as likely to refer a patient with very low recurrence risk (89.3 vs. 98.3 %; p = 0.099), but much less likely to refer a patient with moderate risk (0 vs. 82.8 %; p < 0.001). High-referring physicians were more likely to consider resection for scenarios consistent with higher recurrence risk (31.0 vs. 10.7 %; p = 0.05). Conclusions: We found wide variation in surgical referral patterns for CLM. Many felt that bilobar disease and tumor size were contraindications to liver-directed therapy despite a lack of supporting data. These findings suggest an urgent need to increase dissemination of evidence and guidance regarding management for CLM, perhaps through increased specialist participation in tumor boards.

Original languageEnglish (US)
Pages (from-to)2179-2194
Number of pages16
JournalAnnals of Surgical Oncology
Volume22
Issue number7
DOIs
StatePublished - Jul 8 2015
Externally publishedYes

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Referral and Consultation
Neoplasm Metastasis
Liver
Population
Physicians
Surveys and Questionnaires
Recurrence
Neoplasms
Colorectal Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Krell, R. W., Reames, B. N., Hendren, S., Frankel, T. L., Pawlik, T. M., Chung, M., ... Wong, S. L. (2015). Surgical Referral for Colorectal Liver Metastases: A Population-Based Survey. Annals of Surgical Oncology, 22(7), 2179-2194. https://doi.org/10.1245/s10434-014-4318-x

Surgical Referral for Colorectal Liver Metastases : A Population-Based Survey. / Krell, Robert W.; Reames, Bradley N; Hendren, Samantha; Frankel, Timothy L.; Pawlik, Timothy M.; Chung, Mathew; Kwon, David; Wong, Sandra L.

In: Annals of Surgical Oncology, Vol. 22, No. 7, 08.07.2015, p. 2179-2194.

Research output: Contribution to journalArticle

Krell, RW, Reames, BN, Hendren, S, Frankel, TL, Pawlik, TM, Chung, M, Kwon, D & Wong, SL 2015, 'Surgical Referral for Colorectal Liver Metastases: A Population-Based Survey', Annals of Surgical Oncology, vol. 22, no. 7, pp. 2179-2194. https://doi.org/10.1245/s10434-014-4318-x
Krell, Robert W. ; Reames, Bradley N ; Hendren, Samantha ; Frankel, Timothy L. ; Pawlik, Timothy M. ; Chung, Mathew ; Kwon, David ; Wong, Sandra L. / Surgical Referral for Colorectal Liver Metastases : A Population-Based Survey. In: Annals of Surgical Oncology. 2015 ; Vol. 22, No. 7. pp. 2179-2194.
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abstract = "Background: Surgical resection is underutilized for patients with colorectal liver metastases (CLM). Although the causes of underutilization are poorly understood, provider attitudes towards surgical referral may be contributory. We sought to understand medical oncologists’ perspectives on referral for CLM. Methods: Medical oncologists who treat colorectal cancer in the US state of Michigan were surveyed. We characterized respondents’ attitudes regarding clinical and tumor-related contraindications to liver resection for CLM, as well as referral and treatment preferences using case-based scenarios. We then evaluated practice characteristics and treatment preferences between physicians. Results: A total of 112 eligible responses were received (46 {\%} response rate). Nearly 40 {\%} of respondents reported having no liver surgeons in their practice area. Commonly perceived contraindications to liver resection included extrahepatic disease (80.3 {\%}), poor performance status (77.7 {\%}), the presence of >4 metastases (62.5 {\%}), bilobar metastases (43.8 {\%}), and metastasis size >5 cm (40.2 {\%}). Compared with high-referring physicians, low-referring physicians were just as likely to refer a patient with very low recurrence risk (89.3 vs. 98.3 {\%}; p = 0.099), but much less likely to refer a patient with moderate risk (0 vs. 82.8 {\%}; p < 0.001). High-referring physicians were more likely to consider resection for scenarios consistent with higher recurrence risk (31.0 vs. 10.7 {\%}; p = 0.05). Conclusions: We found wide variation in surgical referral patterns for CLM. Many felt that bilobar disease and tumor size were contraindications to liver-directed therapy despite a lack of supporting data. These findings suggest an urgent need to increase dissemination of evidence and guidance regarding management for CLM, perhaps through increased specialist participation in tumor boards.",
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AU - Chung, Mathew

AU - Kwon, David

AU - Wong, Sandra L.

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AB - Background: Surgical resection is underutilized for patients with colorectal liver metastases (CLM). Although the causes of underutilization are poorly understood, provider attitudes towards surgical referral may be contributory. We sought to understand medical oncologists’ perspectives on referral for CLM. Methods: Medical oncologists who treat colorectal cancer in the US state of Michigan were surveyed. We characterized respondents’ attitudes regarding clinical and tumor-related contraindications to liver resection for CLM, as well as referral and treatment preferences using case-based scenarios. We then evaluated practice characteristics and treatment preferences between physicians. Results: A total of 112 eligible responses were received (46 % response rate). Nearly 40 % of respondents reported having no liver surgeons in their practice area. Commonly perceived contraindications to liver resection included extrahepatic disease (80.3 %), poor performance status (77.7 %), the presence of >4 metastases (62.5 %), bilobar metastases (43.8 %), and metastasis size >5 cm (40.2 %). Compared with high-referring physicians, low-referring physicians were just as likely to refer a patient with very low recurrence risk (89.3 vs. 98.3 %; p = 0.099), but much less likely to refer a patient with moderate risk (0 vs. 82.8 %; p < 0.001). High-referring physicians were more likely to consider resection for scenarios consistent with higher recurrence risk (31.0 vs. 10.7 %; p = 0.05). Conclusions: We found wide variation in surgical referral patterns for CLM. Many felt that bilobar disease and tumor size were contraindications to liver-directed therapy despite a lack of supporting data. These findings suggest an urgent need to increase dissemination of evidence and guidance regarding management for CLM, perhaps through increased specialist participation in tumor boards.

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