Surgical complications in solitary pancreas and combined pancreas-kidney transplantations

Claire F. Ozaki, Robert J. Stratta, Rodney J. Taylor, Alan N. Langnas, J. Steven Bynon, Byers W. Shaw

Research output: Contribution to journalArticle

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Abstract

The benefits of pancreas transplantation (PT) must be weighed against the morbidity associated with the operative procedure and long-term immunosuppression. Over a 32-month period, we performed 73 PTs including 61 combined pancreas-kidney transplants (PKT) and 12 solitary PTs. In the PKT group, 25 reoperations were performed in 18 patients (29.5%) at a mean of 39±12 days after transplant. In the solitary PT group, 16 reoperations were performed in 8 recipients (66.7%, p=0.03) at a mean of 87±12 days after PT (p<0.01). In the PKT group, pancreas allograft survival was 93.4%. Vascular thrombosis resulted in the loss of two pancreas allografts. In the solitary PT group, pancreas allograft survival was 50% (p<0.001), with 6 transplant pancreatectomies performed for either infectious (5) or vascular (1) complications. Surgical complications after PT are common (35.6% in this series), occur earlier in patients who undergo PKT, and are more frequent and morbid in patients undergoing solitary PT, especially after a previous kidney transplant. An aggressive surgical approach can lead to a high rate of pancreas allograft salvage without jeopardizing either the patient or the renal allograft.

Original languageEnglish (US)
Pages (from-to)546-551
Number of pages6
JournalThe American Journal of Surgery
Volume164
Issue number5
DOIs
StatePublished - Nov 1992

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Pancreas Transplantation
Kidney Transplantation
Pancreas
Transplants
Allografts
Kidney
Reoperation
Blood Vessels
Pancreatectomy
Operative Surgical Procedures
Immunosuppression
Thrombosis
Morbidity

ASJC Scopus subject areas

  • Surgery

Cite this

Surgical complications in solitary pancreas and combined pancreas-kidney transplantations. / Ozaki, Claire F.; Stratta, Robert J.; Taylor, Rodney J.; Langnas, Alan N.; Bynon, J. Steven; Shaw, Byers W.

In: The American Journal of Surgery, Vol. 164, No. 5, 11.1992, p. 546-551.

Research output: Contribution to journalArticle

Ozaki, Claire F. ; Stratta, Robert J. ; Taylor, Rodney J. ; Langnas, Alan N. ; Bynon, J. Steven ; Shaw, Byers W. / Surgical complications in solitary pancreas and combined pancreas-kidney transplantations. In: The American Journal of Surgery. 1992 ; Vol. 164, No. 5. pp. 546-551.
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