Surgical approaches to improving intestinal function in the short-bowel syndrome

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Abstract

Hypothesis: Nontransplantation surgical approaches to improve intestinal function in patients with the short-bowel syndrome have a satisfactory outcome in selected patients. Patients: Ninety adult (aged >18 years) patients with intestinal remnants shorter than 180 cm were evaluated between 1980 and 1998. Main Outcome Measures: Clinical improvement (reduction in parenteral nutrition, resolution of anatomical problems, decreased symptoms, or improved oral intake) and postoperative morbidity and mortality rates. Results: There were 17 deaths within 30 days after resection. Thirty-seven (51%) of the surviving 73 patients underwent 43 procedures to improve intestinal function. Fourteen procedures (33%) were intended to expand intestinal surface area by restoring intestinal continuity (n = 10), recruiting additional length (n = 3), or longitudinal lengthening (n = 1). Twenty-six procedures (60%) aimed to alter intestinal function, either by relieving obstruction (n = 10), repairing fistulas (n = 8), slowing transit (n = 4), eliminating diseased bowel (n = 3), or improving motility (n = 1). Three patients had stomas created to improve oral intake and relieve perianal symptoms. Postoperatively, 2 anastomoses leaked, 2 fistulas recurred, and there was 1 death (mortality, 2%). Thirty-seven procedures (86%) resulted in clinical improvement. Eleven (46%) of the 24 patients receiving parenteral nutrition were able to discontinue it and 5 patients were able to reduce the amount of parenteral nutrition received. Twelve procedures that increased surface area (86%) and 22 procedures that addressed functional problems (85%) resulted in clinical improvement. Success was lowest (50%) in patients having procedures to prolong transit time. Conclusions: Various nontransplantation surgical procedures have a role in improving intestinal function in short- bowel syndrome. These procedures usually result in clinical improvement in properly selected patients. Success is lowest for procedures designed to prolong intestinal transit time; thus, these procedures should be used only in carefully selected patients.

Original languageEnglish (US)
Pages (from-to)706-711
Number of pages6
JournalArchives of Surgery
Volume134
Issue number7
DOIs
StatePublished - Jul 1 1999

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Short Bowel Syndrome
Parenteral Nutrition
Fistula
Mortality

ASJC Scopus subject areas

  • Surgery

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Surgical approaches to improving intestinal function in the short-bowel syndrome. / Thompson, Jon S; Langnas, Alan Norman.

In: Archives of Surgery, Vol. 134, No. 7, 01.07.1999, p. 706-711.

Research output: Contribution to journalArticle

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abstract = "Hypothesis: Nontransplantation surgical approaches to improve intestinal function in patients with the short-bowel syndrome have a satisfactory outcome in selected patients. Patients: Ninety adult (aged >18 years) patients with intestinal remnants shorter than 180 cm were evaluated between 1980 and 1998. Main Outcome Measures: Clinical improvement (reduction in parenteral nutrition, resolution of anatomical problems, decreased symptoms, or improved oral intake) and postoperative morbidity and mortality rates. Results: There were 17 deaths within 30 days after resection. Thirty-seven (51{\%}) of the surviving 73 patients underwent 43 procedures to improve intestinal function. Fourteen procedures (33{\%}) were intended to expand intestinal surface area by restoring intestinal continuity (n = 10), recruiting additional length (n = 3), or longitudinal lengthening (n = 1). Twenty-six procedures (60{\%}) aimed to alter intestinal function, either by relieving obstruction (n = 10), repairing fistulas (n = 8), slowing transit (n = 4), eliminating diseased bowel (n = 3), or improving motility (n = 1). Three patients had stomas created to improve oral intake and relieve perianal symptoms. Postoperatively, 2 anastomoses leaked, 2 fistulas recurred, and there was 1 death (mortality, 2{\%}). Thirty-seven procedures (86{\%}) resulted in clinical improvement. Eleven (46{\%}) of the 24 patients receiving parenteral nutrition were able to discontinue it and 5 patients were able to reduce the amount of parenteral nutrition received. Twelve procedures that increased surface area (86{\%}) and 22 procedures that addressed functional problems (85{\%}) resulted in clinical improvement. Success was lowest (50{\%}) in patients having procedures to prolong transit time. Conclusions: Various nontransplantation surgical procedures have a role in improving intestinal function in short- bowel syndrome. These procedures usually result in clinical improvement in properly selected patients. Success is lowest for procedures designed to prolong intestinal transit time; thus, these procedures should be used only in carefully selected patients.",
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