31P MRS studies of exercising human muscle at high temporal resolution

Michael D. Boska, J. A. Nelson, N. Sripathi, I. I. Pipinos, A. D. Shepard, K. M.A. Welch

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Methods for measuring mitochondrial activity from 31P magnetic resonance spectroscopy data collected during and after exercise were compared in controls, weight lifters, and peripheral vascular occlusive disease (PVOD) patients. There were trends toward increasing mitochondrial activity during exercise in order from PVOD patients, moderately active controls, highly active controls, to weight lifters. Results from PVOD patients show divergence of some measures due to 1) the non-exponential nature of phosphocreatine recovery, and 2) potential breakdown of [ADP] control of the mitochondria due to lack of oxygen (for Q(max) calculation). These results demonstrate the utility of obtaining and directly analyzing high time resolution data rather than assuming monoexponential behavior of metabolite recovery.

Original languageEnglish (US)
Pages (from-to)1145-1151
Number of pages7
JournalMagnetic Resonance in Medicine
Volume41
Issue number6
DOIs
StatePublished - Jun 7 1999

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Peripheral Vascular Diseases
Muscles
Exercise
Weights and Measures
Phosphocreatine
Adenosine Diphosphate
Mitochondria
Magnetic Resonance Spectroscopy
Oxygen

Keywords

  • Isometric exercise
  • Mitochondrial activity
  • Muscle ATP production
  • P MRS

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

31P MRS studies of exercising human muscle at high temporal resolution. / Boska, Michael D.; Nelson, J. A.; Sripathi, N.; Pipinos, I. I.; Shepard, A. D.; Welch, K. M.A.

In: Magnetic Resonance in Medicine, Vol. 41, No. 6, 07.06.1999, p. 1145-1151.

Research output: Contribution to journalArticle

Boska, Michael D. ; Nelson, J. A. ; Sripathi, N. ; Pipinos, I. I. ; Shepard, A. D. ; Welch, K. M.A. / 31P MRS studies of exercising human muscle at high temporal resolution. In: Magnetic Resonance in Medicine. 1999 ; Vol. 41, No. 6. pp. 1145-1151.
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