SUMOylation in ocular development and pathology

L. Gong, D. W.C. Li

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

SUMOylation, a posttranslational modification process in which SUMO, the small ubiquitin-related modifier or small ubiquitin-like modifier, is added to the target proteins, plays an important role in regulating a variety of cellular processes including protein-protein interactions, subcellular localization, protein-DNA interactions and enzyme activity. This process adds another layer of control in eukaryote gene expression, and it regulates both transcriptional activation and repression. In the present review, we summarized the currently emerging information regarding the function of SUMOylation in ocular development and pathology.

Original languageEnglish (US)
Pages (from-to)794-801
Number of pages8
JournalCurrent Molecular Medicine
Volume10
Issue number9
DOIs
StatePublished - Dec 1 2010

Fingerprint

Sumoylation
Pathology
Ubiquitin
Proteins
Enzyme activity
Post Translational Protein Processing
Eukaryota
Gene expression
Transcriptional Activation
Chemical activation
Gene Expression
DNA
Enzymes

Keywords

  • Cornea
  • Development
  • Differentiation
  • Gene expression
  • LEDGF
  • Lens
  • Nr2e3
  • Nrl
  • Pax-6
  • Retina
  • SUMOylation
  • Signal transduction

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

Cite this

SUMOylation in ocular development and pathology. / Gong, L.; Li, D. W.C.

In: Current Molecular Medicine, Vol. 10, No. 9, 01.12.2010, p. 794-801.

Research output: Contribution to journalArticle

Gong, L. ; Li, D. W.C. / SUMOylation in ocular development and pathology. In: Current Molecular Medicine. 2010 ; Vol. 10, No. 9. pp. 794-801.
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