SUMOylation in neurological diseases

F. Y. Liu, Y. F. Liu, Y. Yang, Z. W. Luo, J. W. Xiang, Z. G. Chen, R. L. Qi, T. H. Yang, Y. Xiao, W. J. Qing, D. W C Li

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Since the discovery of SUMOs (small ubiquitin-like modifiers) over 20 years ago, sumoylation has recently emerged as an important posttranslational modification involved in almost all aspects of cellular physiology. In neurons, sumoylation dynamically modulates protein function and consequently plays an important role in neuronal maturation, synapse formation and plasticity. Thus, the dysfunction of sumoylation pathway is associated with many different neurological disorders. Hundreds of different proteins implicated in the pathogenesis of neurological disorders are SUMO-modified, indicating the importance of sumoylation involved in the neurological diseases. In this review, we summarize the growing findings on protein sumoylation in neuronal function and dysfunction. It is essential to have a thorough understanding on the mechanism how sumoylation contributes to neurological diseases in developing efficient therapy for these diseases.

Original languageEnglish (US)
Pages (from-to)893-899
Number of pages7
JournalCurrent Molecular Medicine
Volume16
Issue number10
DOIs
StatePublished - Dec 1 2016
Externally publishedYes

Fingerprint

Sumoylation
Ubiquitin
Proteins
Physiology
Nervous System Diseases
Neurons
Plasticity
Post Translational Protein Processing
Synapses

Keywords

  • Neurological diseases
  • Neuronal function
  • Sumoylation
  • Synapse formation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

Cite this

Liu, F. Y., Liu, Y. F., Yang, Y., Luo, Z. W., Xiang, J. W., Chen, Z. G., ... Li, D. W. C. (2016). SUMOylation in neurological diseases. Current Molecular Medicine, 16(10), 893-899. https://doi.org/10.2174/1566524017666170109125256

SUMOylation in neurological diseases. / Liu, F. Y.; Liu, Y. F.; Yang, Y.; Luo, Z. W.; Xiang, J. W.; Chen, Z. G.; Qi, R. L.; Yang, T. H.; Xiao, Y.; Qing, W. J.; Li, D. W C.

In: Current Molecular Medicine, Vol. 16, No. 10, 01.12.2016, p. 893-899.

Research output: Contribution to journalReview article

Liu, FY, Liu, YF, Yang, Y, Luo, ZW, Xiang, JW, Chen, ZG, Qi, RL, Yang, TH, Xiao, Y, Qing, WJ & Li, DWC 2016, 'SUMOylation in neurological diseases', Current Molecular Medicine, vol. 16, no. 10, pp. 893-899. https://doi.org/10.2174/1566524017666170109125256
Liu FY, Liu YF, Yang Y, Luo ZW, Xiang JW, Chen ZG et al. SUMOylation in neurological diseases. Current Molecular Medicine. 2016 Dec 1;16(10):893-899. https://doi.org/10.2174/1566524017666170109125256
Liu, F. Y. ; Liu, Y. F. ; Yang, Y. ; Luo, Z. W. ; Xiang, J. W. ; Chen, Z. G. ; Qi, R. L. ; Yang, T. H. ; Xiao, Y. ; Qing, W. J. ; Li, D. W C. / SUMOylation in neurological diseases. In: Current Molecular Medicine. 2016 ; Vol. 16, No. 10. pp. 893-899.
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