Successful unrelated cord blood transplantation for homozygous α-thalassemia

Burak Gumuscu, Elizabeth I. Thompson, Alfred C. Grovas, Terrence L. Zach, Phyllis Irene Warkentin, Peter F. Coccia

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

A now 10-year-old Laotian female was delivered at 30-week gestation by cesarean section because of severe hydrops. Fetal blood sampling revealed homozygous α-thalassemia. After immediate resuscitation, the infant was supported with frequent red cell transfusions. At 44 months of age, she received a 5 of 6 human leukocyte antigen-matched unrelated cord blood transplantation. She was treated with phlebotomy and chelation therapy with Deferasirox for correction of hemosiderosis and has been transfusion-independent since 41 days after transplant. She is currently 6 years after transplantation with stable, 100% donor engraftment, resolved iron overload, and normal growth and development.

Original languageEnglish (US)
Pages (from-to)570-572
Number of pages3
JournalJournal of Pediatric Hematology/Oncology
Volume35
Issue number7
DOIs
Publication statusPublished - Oct 1 2013

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Keywords

  • cord blood transplantation
  • homozygous α-thalassemia
  • hydrops fetalis
  • stem cell transplantation for hemoglobinopathies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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