Successful unrelated cord blood transplantation for homozygous α-thalassemia

Burak Gumuscu, Elizabeth I. Thompson, Alfred C. Grovas, Terrence L. Zach, Phyllis Irene Warkentin, Peter F. Coccia

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A now 10-year-old Laotian female was delivered at 30-week gestation by cesarean section because of severe hydrops. Fetal blood sampling revealed homozygous α-thalassemia. After immediate resuscitation, the infant was supported with frequent red cell transfusions. At 44 months of age, she received a 5 of 6 human leukocyte antigen-matched unrelated cord blood transplantation. She was treated with phlebotomy and chelation therapy with Deferasirox for correction of hemosiderosis and has been transfusion-independent since 41 days after transplant. She is currently 6 years after transplantation with stable, 100% donor engraftment, resolved iron overload, and normal growth and development.

Original languageEnglish (US)
Pages (from-to)570-572
Number of pages3
JournalJournal of Pediatric Hematology/Oncology
Volume35
Issue number7
DOIs
StatePublished - Oct 1 2013

Fingerprint

Thalassemia
Fetal Blood
Transplantation
Hemosiderosis
Chelation Therapy
Iron Overload
Phlebotomy
HLA Antigens
Growth and Development
Resuscitation
Cesarean Section
Edema
Tissue Donors
Transplants
Pregnancy
deferasirox

Keywords

  • cord blood transplantation
  • homozygous α-thalassemia
  • hydrops fetalis
  • stem cell transplantation for hemoglobinopathies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Successful unrelated cord blood transplantation for homozygous α-thalassemia. / Gumuscu, Burak; Thompson, Elizabeth I.; Grovas, Alfred C.; Zach, Terrence L.; Warkentin, Phyllis Irene; Coccia, Peter F.

In: Journal of Pediatric Hematology/Oncology, Vol. 35, No. 7, 01.10.2013, p. 570-572.

Research output: Contribution to journalArticle

Gumuscu, Burak ; Thompson, Elizabeth I. ; Grovas, Alfred C. ; Zach, Terrence L. ; Warkentin, Phyllis Irene ; Coccia, Peter F. / Successful unrelated cord blood transplantation for homozygous α-thalassemia. In: Journal of Pediatric Hematology/Oncology. 2013 ; Vol. 35, No. 7. pp. 570-572.
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