Successful renal transplantation in patients with chronic granulomatous disease

A. Bolanowski, R. B. Mannon, S. M. Holland, H. L. Malech, J. Aschan, J. Palmblad, D. A. Hale, A. D. Kirk

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Chronic granulomatous disease (CGD) is a genetic disease caused by structural mutations in the enzyme NADPH oxidase that results in severe immunodeficiency. End-stage renal disease occurs in this patient population, and is often attributed to the necessary use of nephrotoxic anti-infectives. In this report, we present the experiences of two centers in transplantation of three patients with CGD: one transplanted with CGD, one cured of his CGD with bone marrow transplantation who subsequently underwent kidney transplantation and one that received a kidney transplant prior to being cured of CGD via a sequential peripheral blood stem cell transplant (SCT). All three recipients have enjoyed excellent outcomes. Their courses demonstrate the absolute requirements for a multidisciplinary and compulsive approach before, during and after transplantation. These case reports also highlight the unexpectedly benign effects of immunosuppressive therapy in this patient population.

Original languageEnglish (US)
Pages (from-to)636-639
Number of pages4
JournalAmerican Journal of Transplantation
Volume6
Issue number3
DOIs
StatePublished - Mar 1 2006

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Keywords

  • Chronic granulomatous disease
  • Kidney
  • Transplant

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

Bolanowski, A., Mannon, R. B., Holland, S. M., Malech, H. L., Aschan, J., Palmblad, J., Hale, D. A., & Kirk, A. D. (2006). Successful renal transplantation in patients with chronic granulomatous disease. American Journal of Transplantation, 6(3), 636-639. https://doi.org/10.1111/j.1600-6143.2006.01232.x