Successful application of extracorporeal liver perfusion: A technology whose time has come

I. J. Fox, Alan Norman Langnas, L. W. Fristoe, M. S. Shaefer, J. E. Vogel, D. L. Antonson, J. P. Donovan, T. G. Heffron, Rodney Smith Markin, Michael Floyd Sorrell, B. W. Shaw

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

We have used extracorporeal liver perfusion (ECLP) to aid in the management of three patients with fulminant hepatic failure (FHF). Organs were used for ECLP only if they would have gone otherwise unused through United Network for Organ Sharing. In all three patients treated, serial serum bilirubin and arterial ammonia values trended toward the normal range. The neurologic examinations improved dramatically in two patients, and metabolic function of the extracorporeally perfused livers was unequivocally demonstrated by the clearance of theophylline in the last two patients. Two patients ultimately had successful liver transplants, whereas the third patient failed to improve neurologically despite evidence of metabolic function by the extracorporeally perfused liver, and died 7 days after ECLP was discontinued, from pulmonary and renal failure. These studies suggest that, 30 yr after initial clinical trials, ECLP can be applied safely without the need for arterial access 1) as a bridge to transplantation, 2) to assess whether patients in FHF will benefit from improved hepatic function and therefore transplantation, and 3) potentially, to evaluate the 'usability' of questionable donor organs.

Original languageEnglish (US)
Pages (from-to)1876-1881
Number of pages6
JournalAmerican Journal of Gastroenterology
Volume88
Issue number11
StatePublished - Jan 1 1993

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Perfusion
Technology
Liver
Acute Liver Failure
Transplantation
Neurologic Examination
Theophylline
Bilirubin
Ammonia
Renal Insufficiency
Reference Values
Tissue Donors
Clinical Trials
Transplants
Lung
Serum

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Fox, I. J., Langnas, A. N., Fristoe, L. W., Shaefer, M. S., Vogel, J. E., Antonson, D. L., ... Shaw, B. W. (1993). Successful application of extracorporeal liver perfusion: A technology whose time has come. American Journal of Gastroenterology, 88(11), 1876-1881.

Successful application of extracorporeal liver perfusion : A technology whose time has come. / Fox, I. J.; Langnas, Alan Norman; Fristoe, L. W.; Shaefer, M. S.; Vogel, J. E.; Antonson, D. L.; Donovan, J. P.; Heffron, T. G.; Markin, Rodney Smith; Sorrell, Michael Floyd; Shaw, B. W.

In: American Journal of Gastroenterology, Vol. 88, No. 11, 01.01.1993, p. 1876-1881.

Research output: Contribution to journalArticle

Fox, IJ, Langnas, AN, Fristoe, LW, Shaefer, MS, Vogel, JE, Antonson, DL, Donovan, JP, Heffron, TG, Markin, RS, Sorrell, MF & Shaw, BW 1993, 'Successful application of extracorporeal liver perfusion: A technology whose time has come', American Journal of Gastroenterology, vol. 88, no. 11, pp. 1876-1881.
Fox IJ, Langnas AN, Fristoe LW, Shaefer MS, Vogel JE, Antonson DL et al. Successful application of extracorporeal liver perfusion: A technology whose time has come. American Journal of Gastroenterology. 1993 Jan 1;88(11):1876-1881.
Fox, I. J. ; Langnas, Alan Norman ; Fristoe, L. W. ; Shaefer, M. S. ; Vogel, J. E. ; Antonson, D. L. ; Donovan, J. P. ; Heffron, T. G. ; Markin, Rodney Smith ; Sorrell, Michael Floyd ; Shaw, B. W. / Successful application of extracorporeal liver perfusion : A technology whose time has come. In: American Journal of Gastroenterology. 1993 ; Vol. 88, No. 11. pp. 1876-1881.
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