Subthreshold linear modeling of dendritic trees: A computational approach

Alireza Khodaei, Massimiliano Pierobon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The design of communication systems based on the transmission of information through neurons is envisioned as a key technology for the pervasive interconnection of future wearable and implantable devices. While previous literature has mainly focused on modeling propagation of electrochemical spikes carrying natural information through the nervous system, in recent work the authors of this paper proposed the so-called subthreshold electrical stimulation as a viable technique to propagate artificial information through neurons. This technique promises to limit the interference with natural communication processes, and it can be successfully approximated with linear models. In this paper, a novel model is proposed to account for the subthreshold stimuli propagation from the dendritic tree to the soma of a neuron. A computational approach is detailed to obtain this model for a given realistic 3D dendritic tree with an arbitrary morphology. Numerical results from the model are obtained over a stimulation signal bandwidth of 1KHz, and compared with the results of a simulation through the NEURON software.

Original languageEnglish (US)
Title of host publication2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages235-238
Number of pages4
ISBN (Electronic)9781457702204
DOIs
StatePublished - Oct 13 2016
Event38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 - Orlando, United States
Duration: Aug 16 2016Aug 20 2016

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume2016-October
ISSN (Print)1557-170X

Other

Other38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
CountryUnited States
CityOrlando
Period8/16/168/20/16

Fingerprint

Neurons
Carisoprodol
Nervous System
Electric Stimulation
Linear Models
Neurology
Software
Technology
Equipment and Supplies
Communication systems
Bandwidth
Communication

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Khodaei, A., & Pierobon, M. (2016). Subthreshold linear modeling of dendritic trees: A computational approach. In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 (pp. 235-238). [7590683] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2016-October). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2016.7590683

Subthreshold linear modeling of dendritic trees : A computational approach. / Khodaei, Alireza; Pierobon, Massimiliano.

2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Institute of Electrical and Electronics Engineers Inc., 2016. p. 235-238 7590683 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2016-October).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Khodaei, A & Pierobon, M 2016, Subthreshold linear modeling of dendritic trees: A computational approach. in 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016., 7590683, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2016-October, Institute of Electrical and Electronics Engineers Inc., pp. 235-238, 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, United States, 8/16/16. https://doi.org/10.1109/EMBC.2016.7590683
Khodaei A, Pierobon M. Subthreshold linear modeling of dendritic trees: A computational approach. In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Institute of Electrical and Electronics Engineers Inc. 2016. p. 235-238. 7590683. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2016.7590683
Khodaei, Alireza ; Pierobon, Massimiliano. / Subthreshold linear modeling of dendritic trees : A computational approach. 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Institute of Electrical and Electronics Engineers Inc., 2016. pp. 235-238 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).
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