Subcellular distribution and properties of intestinal histamine-metabolizing enzymes from rats, guinea pigs and rhesus monkeys

Stephen L Taylor, E. R. Lieber

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

1. Histamine-N-methyltransferase (HMT) from jejunal mucosa of rats, guinea pigs and rhesus monkeys was localized in the soluble fraction. 2. Diamine oxidase (DAO) from jejunal mucosa of rats and rhesus monkeys was localized in the soluble fraction. 3. Guinea pig jejunal mucosa had no observable DAO activity. 4. The Km's observed for jejunal mucosa HMT were 33.2 μM for rat, 114 μM for rhesus monkey and 7.1 μM for guinea pig. 5. The Km's observed for jejunal mucosa DAO were 0.21 mM for rat and 0.26 mM for rhesus monkey. 6. Substrate inhibition was encountered at high substrate concentrations with rat HMT and rat and monkey DAO.

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume63
Issue number1
DOIs
StatePublished - Jan 1 1979

Fingerprint

Macaca mulatta
Histamine
Amine Oxidase (Copper-Containing)
Guinea Pigs
Histamine N-Methyltransferase
Mucous Membrane
Enzymes
Haplorhini

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{faba47c6f961474caf10880e7720ca64,
title = "Subcellular distribution and properties of intestinal histamine-metabolizing enzymes from rats, guinea pigs and rhesus monkeys",
abstract = "1. Histamine-N-methyltransferase (HMT) from jejunal mucosa of rats, guinea pigs and rhesus monkeys was localized in the soluble fraction. 2. Diamine oxidase (DAO) from jejunal mucosa of rats and rhesus monkeys was localized in the soluble fraction. 3. Guinea pig jejunal mucosa had no observable DAO activity. 4. The Km's observed for jejunal mucosa HMT were 33.2 μM for rat, 114 μM for rhesus monkey and 7.1 μM for guinea pig. 5. The Km's observed for jejunal mucosa DAO were 0.21 mM for rat and 0.26 mM for rhesus monkey. 6. Substrate inhibition was encountered at high substrate concentrations with rat HMT and rat and monkey DAO.",
author = "Taylor, {Stephen L} and Lieber, {E. R.}",
year = "1979",
month = "1",
day = "1",
doi = "10.1016/0306-4492(79)90124-2",
language = "English (US)",
volume = "63",
pages = "21--26",
journal = "Comparative biochemistry and physiology. C: Comparative pharmacology",
issn = "0742-8413",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Subcellular distribution and properties of intestinal histamine-metabolizing enzymes from rats, guinea pigs and rhesus monkeys

AU - Taylor, Stephen L

AU - Lieber, E. R.

PY - 1979/1/1

Y1 - 1979/1/1

N2 - 1. Histamine-N-methyltransferase (HMT) from jejunal mucosa of rats, guinea pigs and rhesus monkeys was localized in the soluble fraction. 2. Diamine oxidase (DAO) from jejunal mucosa of rats and rhesus monkeys was localized in the soluble fraction. 3. Guinea pig jejunal mucosa had no observable DAO activity. 4. The Km's observed for jejunal mucosa HMT were 33.2 μM for rat, 114 μM for rhesus monkey and 7.1 μM for guinea pig. 5. The Km's observed for jejunal mucosa DAO were 0.21 mM for rat and 0.26 mM for rhesus monkey. 6. Substrate inhibition was encountered at high substrate concentrations with rat HMT and rat and monkey DAO.

AB - 1. Histamine-N-methyltransferase (HMT) from jejunal mucosa of rats, guinea pigs and rhesus monkeys was localized in the soluble fraction. 2. Diamine oxidase (DAO) from jejunal mucosa of rats and rhesus monkeys was localized in the soluble fraction. 3. Guinea pig jejunal mucosa had no observable DAO activity. 4. The Km's observed for jejunal mucosa HMT were 33.2 μM for rat, 114 μM for rhesus monkey and 7.1 μM for guinea pig. 5. The Km's observed for jejunal mucosa DAO were 0.21 mM for rat and 0.26 mM for rhesus monkey. 6. Substrate inhibition was encountered at high substrate concentrations with rat HMT and rat and monkey DAO.

UR - http://www.scopus.com/inward/record.url?scp=0018766253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018766253&partnerID=8YFLogxK

U2 - 10.1016/0306-4492(79)90124-2

DO - 10.1016/0306-4492(79)90124-2

M3 - Article

VL - 63

SP - 21

EP - 26

JO - Comparative biochemistry and physiology. C: Comparative pharmacology

JF - Comparative biochemistry and physiology. C: Comparative pharmacology

SN - 0742-8413

IS - 1

ER -