Subantimicrobial dose doxycycline effects on alveolar bone loss in post-menopausal women

Jeffrey B Payne, Julie A. Stoner, Pirkka V. Nummikoski, Richard A Reinhardt, Arthur D. Goren, Mark S. Wolff, Hsi Ming Lee, James C. Lynch, Robert Valente, Lorne M. Golub

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Aim: Determine the efficacy of 2-year continuous subantimicrobial dose doxycycline (SDD; 20 mg bid) on alveolar bone in post-menopausal osteopenic, oestrogen-deficient women undergoing periodontal maintenance in a 2-year double-blind, placebo-controlled, randomized clinical trial. Material and Methods: One-hundred and twenty-eight subjects randomized to SDD or placebo (n=64 each). Posterior vertical bite wings taken at baseline, 1 and 2 years for alveolar bone density (ABD), using radiographic absorptiometry (RA) and computer-assisted densitometric image analysis (CADIA), and alveolar bone height (ABH). Statistical analyses utilized generalized estimating equations; primary analyses were intent to treat (ITT). Results are presented as SDD versus placebo. Results: Under ITT, there was no statistically significant effect of SDD on ABD loss (RA: p=0.8; CADIA: p=0.2) or ABH loss (p=0.2). Most sites (81-95%) were inactive. For subgroup analyses, mean CADIA was higher with SDD for non-smokers (p=0.05) and baseline probing depths ≥5 mm (p=0.003). SDD was associated with 29% lower odds of more progressive ABH loss in women >5 years post-menopausal (p=0.05) and 36% lower among protocol-adherent subjects (p=0.03). Conclusions: In post-menopausal osteopenic women with periodontitis, SDD did not differ overall from placebo. Based on exploratory subgroup analyses, additional research is needed to determine the usefulness of SDD in non-smokers, subjects >5 years post-menopausal and in deeper pockets.Protocol registered at ClinicalTrials.gov. Identifier: NCT00066027

Original languageEnglish (US)
Pages (from-to)776-787
Number of pages12
JournalJournal of Clinical Periodontology
Volume34
Issue number9
DOIs
StatePublished - Sep 1 2007

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Alveolar Bone Loss
Doxycycline
Computer-Assisted Image Processing
Placebos
Bone Density
Bone and Bones
Periodontitis
Bites and Stings
Estrogens
Randomized Controlled Trials
Maintenance
Research

Keywords

  • Computer-assisted densitometric image analysis (CADIA)
  • Dual-energy X-ray absorptiometry (DEXA)
  • Osteopenia
  • Periodontal maintenance
  • Periodontitis
  • Post-menopausal
  • Radiographic absorptiometry (RA) method
  • Randomized clinical trial

ASJC Scopus subject areas

  • Periodontics

Cite this

Subantimicrobial dose doxycycline effects on alveolar bone loss in post-menopausal women. / Payne, Jeffrey B; Stoner, Julie A.; Nummikoski, Pirkka V.; Reinhardt, Richard A; Goren, Arthur D.; Wolff, Mark S.; Lee, Hsi Ming; Lynch, James C.; Valente, Robert; Golub, Lorne M.

In: Journal of Clinical Periodontology, Vol. 34, No. 9, 01.09.2007, p. 776-787.

Research output: Contribution to journalArticle

Payne, JB, Stoner, JA, Nummikoski, PV, Reinhardt, RA, Goren, AD, Wolff, MS, Lee, HM, Lynch, JC, Valente, R & Golub, LM 2007, 'Subantimicrobial dose doxycycline effects on alveolar bone loss in post-menopausal women', Journal of Clinical Periodontology, vol. 34, no. 9, pp. 776-787. https://doi.org/10.1111/j.1600-051X.2007.01115.x
Payne, Jeffrey B ; Stoner, Julie A. ; Nummikoski, Pirkka V. ; Reinhardt, Richard A ; Goren, Arthur D. ; Wolff, Mark S. ; Lee, Hsi Ming ; Lynch, James C. ; Valente, Robert ; Golub, Lorne M. / Subantimicrobial dose doxycycline effects on alveolar bone loss in post-menopausal women. In: Journal of Clinical Periodontology. 2007 ; Vol. 34, No. 9. pp. 776-787.
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AU - Reinhardt, Richard A

AU - Goren, Arthur D.

AU - Wolff, Mark S.

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KW - Radiographic absorptiometry (RA) method

KW - Randomized clinical trial

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