Studies of in vivo phosphorylated proteins in BC3H-1 myocytes suggest that protein kinase C is involved in insulin action

María del C. Vila, Denise R. Cooper, John S. Davis, Mary L. Standaert, Robert V. Farese

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Insulin (10 and 100 nM) and phorbol esters increased the phosphorylation of several proteins, including 40, 47 and 80 kDa proteins, which are markers for protein kinase C activation. Insulin effects were evident at 2 min and increased over 20 min. These findings suggest that insulin activates protein kinase C in BC3H-1 myocytes.

Original languageEnglish (US)
Pages (from-to)177-180
Number of pages4
JournalFEBS Letters
Volume244
Issue number1
DOIs
StatePublished - Feb 13 1989

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Keywords

  • Diacylglycerol
  • Insulin
  • Myocyte
  • Phorbol ester
  • Phospholipid
  • Protein kinase C
  • Protein phosphorylation

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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