Structure of clostridium difficile pilj exhibits unprecedented divergence from known type iv pilins

Kurt H. Piepenbrink, Grace A. Maldarelli, Claudia F.Martinez De La Peña, George L. Mulvey, Greg A. Snyder, Leon De Masi, Erik C. Von Rosenvinge, Sebastian Günther, Glen D. Armstrong, Michael S. Donnenberg, Eric J. Sundberg

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Background: Type IV pili are non-covalently assembled appendages, characterized now in both Gram-negative and Grampositive bacteria. Results: Clostridium difficile produces Type IV pili containing PilJ, a pilin with a novel dual-pilin fold. Conclusion: Models suggest that the C-terminal pilin domain is exposed in pili, providing a unique interaction surface. Significance: The novel fold of PilJ suggests a new mode for Type IV pilus function.

Original languageEnglish (US)
Pages (from-to)4334-4345
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number7
DOIs
StatePublished - Feb 14 2014

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Piepenbrink, K. H., Maldarelli, G. A., De La Peña, C. F. M., Mulvey, G. L., Snyder, G. A., De Masi, L., Von Rosenvinge, E. C., Günther, S., Armstrong, G. D., Donnenberg, M. S., & Sundberg, E. J. (2014). Structure of clostridium difficile pilj exhibits unprecedented divergence from known type iv pilins. Journal of Biological Chemistry, 289(7), 4334-4345. https://doi.org/10.1074/jbc.M113.534404