Structure and reactivity of hexacoordinate hemoglobins

Smita Kakar, Federico G. Hoffman, Jay F Storz, Marian Fabian, Mark S. Hargrove

Research output: Contribution to journalReview article

89 Citations (Scopus)

Abstract

The heme prosthetic group in hemoglobins is most often attached to the globin through coordination of either one or two histidine side chains. Those proteins with one histidine coordinating the heme iron are called "pentacoordinate" hemoglobins, a group represented by red blood cell hemoglobin and most other oxygen transporters. Those with two histidines are called "hexacoordinate hemoglobins", which have broad representation among eukaryotes. Coordination of the second histidine in hexacoordinate Hbs is reversible, allowing for binding of exogenous ligands like oxygen, carbon monoxide, and nitric oxide. Research over the past several years has produced a fairly detailed picture of the structure and biochemistry of hexacoordinate hemoglobins from several species including neuroglobin and cytoglobin in animals, and the nonsymbiotic hemoglobins in plants. However, a clear understanding of the physiological functions of these proteins remains an elusive goal.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalBiophysical Chemistry
Volume152
Issue number1-3
DOIs
StatePublished - Nov 1 2010

Fingerprint

Hemoglobins
Histidine
Heme
Oxygen
Biochemistry
Globins
Carbon Monoxide
Prosthetics
Eukaryota
Nitric Oxide
Animals
Proteins
Blood
Iron
Erythrocytes
Cells
Ligands
Research

Keywords

  • Evolution
  • Hexacoordinate hemoglobin
  • Kinetics
  • Ligand binding
  • Neuroglobin
  • Plant hemoglobin
  • Structure

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Organic Chemistry

Cite this

Structure and reactivity of hexacoordinate hemoglobins. / Kakar, Smita; Hoffman, Federico G.; Storz, Jay F; Fabian, Marian; Hargrove, Mark S.

In: Biophysical Chemistry, Vol. 152, No. 1-3, 01.11.2010, p. 1-14.

Research output: Contribution to journalReview article

Kakar, S, Hoffman, FG, Storz, JF, Fabian, M & Hargrove, MS 2010, 'Structure and reactivity of hexacoordinate hemoglobins', Biophysical Chemistry, vol. 152, no. 1-3, pp. 1-14. https://doi.org/10.1016/j.bpc.2010.08.008
Kakar, Smita ; Hoffman, Federico G. ; Storz, Jay F ; Fabian, Marian ; Hargrove, Mark S. / Structure and reactivity of hexacoordinate hemoglobins. In: Biophysical Chemistry. 2010 ; Vol. 152, No. 1-3. pp. 1-14.
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