Structure and expression of the human and mouse T4 genes.

P. J. Maddon, S. M. Molineaux, D. E. Maddon, K. A. Zimmerman, M. Godfrey, F. W. Alt, L. Chess, R. Axel

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

The T4 molecule may serve as a T-cell receptor recognizing molecules on the surface of specific target cells and also serves as the receptor for the human immunodeficiency virus. To define the mechanisms of interaction of T4 with the surface of antigen-presenting cells as well as with human immunodeficiency virus, we have further analyzed the sequence, structure, and expression of the human and mouse T4 genes. T4 consists of an extracellular segment comprised of a leader sequence followed by four tandem variable-joining (VJ)-like domains, a transmembrane domain, and a cytoplasmic segment. The structural domains of the T4 protein deduced from amino acid sequence are precisely reflected in the intron-exon organization of the gene. Analysis of the expression of the T4 gene indicates that T4 RNA is expressed not only in T lymphocytes, but in B cells, macrophages, and granulocytes. T4 is also expressed in a developmentally regulated manner in specific regions of the brain. It is, therefore, possible that T4 plays a more general role in mediating cell recognition events that are not restricted to the cellular immune response.

Original languageEnglish (US)
Pages (from-to)9155-9159
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume84
Issue number24
DOIs
StatePublished - Dec 1987

Fingerprint

HIV
Antigen-Presenting Cells
Surface Antigens
T-Cell Antigen Receptor
Granulocytes
Cellular Immunity
Introns
Genes
Amino Acid Sequence
Exons
B-Lymphocytes
Macrophages
RNA
T-Lymphocytes
Gene Expression
Brain
Protein Domains

ASJC Scopus subject areas

  • General

Cite this

Structure and expression of the human and mouse T4 genes. / Maddon, P. J.; Molineaux, S. M.; Maddon, D. E.; Zimmerman, K. A.; Godfrey, M.; Alt, F. W.; Chess, L.; Axel, R.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, No. 24, 12.1987, p. 9155-9159.

Research output: Contribution to journalArticle

Maddon, PJ, Molineaux, SM, Maddon, DE, Zimmerman, KA, Godfrey, M, Alt, FW, Chess, L & Axel, R 1987, 'Structure and expression of the human and mouse T4 genes.', Proceedings of the National Academy of Sciences of the United States of America, vol. 84, no. 24, pp. 9155-9159. https://doi.org/10.1073/pnas.84.24.9155
Maddon, P. J. ; Molineaux, S. M. ; Maddon, D. E. ; Zimmerman, K. A. ; Godfrey, M. ; Alt, F. W. ; Chess, L. ; Axel, R. / Structure and expression of the human and mouse T4 genes. In: Proceedings of the National Academy of Sciences of the United States of America. 1987 ; Vol. 84, No. 24. pp. 9155-9159.
@article{f1c0882a85c8463996b4300c948383c9,
title = "Structure and expression of the human and mouse T4 genes.",
abstract = "The T4 molecule may serve as a T-cell receptor recognizing molecules on the surface of specific target cells and also serves as the receptor for the human immunodeficiency virus. To define the mechanisms of interaction of T4 with the surface of antigen-presenting cells as well as with human immunodeficiency virus, we have further analyzed the sequence, structure, and expression of the human and mouse T4 genes. T4 consists of an extracellular segment comprised of a leader sequence followed by four tandem variable-joining (VJ)-like domains, a transmembrane domain, and a cytoplasmic segment. The structural domains of the T4 protein deduced from amino acid sequence are precisely reflected in the intron-exon organization of the gene. Analysis of the expression of the T4 gene indicates that T4 RNA is expressed not only in T lymphocytes, but in B cells, macrophages, and granulocytes. T4 is also expressed in a developmentally regulated manner in specific regions of the brain. It is, therefore, possible that T4 plays a more general role in mediating cell recognition events that are not restricted to the cellular immune response.",
author = "Maddon, {P. J.} and Molineaux, {S. M.} and Maddon, {D. E.} and Zimmerman, {K. A.} and M. Godfrey and Alt, {F. W.} and L. Chess and R. Axel",
year = "1987",
month = "12",
doi = "10.1073/pnas.84.24.9155",
language = "English (US)",
volume = "84",
pages = "9155--9159",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "24",

}

TY - JOUR

T1 - Structure and expression of the human and mouse T4 genes.

AU - Maddon, P. J.

AU - Molineaux, S. M.

AU - Maddon, D. E.

AU - Zimmerman, K. A.

AU - Godfrey, M.

AU - Alt, F. W.

AU - Chess, L.

AU - Axel, R.

PY - 1987/12

Y1 - 1987/12

N2 - The T4 molecule may serve as a T-cell receptor recognizing molecules on the surface of specific target cells and also serves as the receptor for the human immunodeficiency virus. To define the mechanisms of interaction of T4 with the surface of antigen-presenting cells as well as with human immunodeficiency virus, we have further analyzed the sequence, structure, and expression of the human and mouse T4 genes. T4 consists of an extracellular segment comprised of a leader sequence followed by four tandem variable-joining (VJ)-like domains, a transmembrane domain, and a cytoplasmic segment. The structural domains of the T4 protein deduced from amino acid sequence are precisely reflected in the intron-exon organization of the gene. Analysis of the expression of the T4 gene indicates that T4 RNA is expressed not only in T lymphocytes, but in B cells, macrophages, and granulocytes. T4 is also expressed in a developmentally regulated manner in specific regions of the brain. It is, therefore, possible that T4 plays a more general role in mediating cell recognition events that are not restricted to the cellular immune response.

AB - The T4 molecule may serve as a T-cell receptor recognizing molecules on the surface of specific target cells and also serves as the receptor for the human immunodeficiency virus. To define the mechanisms of interaction of T4 with the surface of antigen-presenting cells as well as with human immunodeficiency virus, we have further analyzed the sequence, structure, and expression of the human and mouse T4 genes. T4 consists of an extracellular segment comprised of a leader sequence followed by four tandem variable-joining (VJ)-like domains, a transmembrane domain, and a cytoplasmic segment. The structural domains of the T4 protein deduced from amino acid sequence are precisely reflected in the intron-exon organization of the gene. Analysis of the expression of the T4 gene indicates that T4 RNA is expressed not only in T lymphocytes, but in B cells, macrophages, and granulocytes. T4 is also expressed in a developmentally regulated manner in specific regions of the brain. It is, therefore, possible that T4 plays a more general role in mediating cell recognition events that are not restricted to the cellular immune response.

UR - http://www.scopus.com/inward/record.url?scp=0023478699&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023478699&partnerID=8YFLogxK

U2 - 10.1073/pnas.84.24.9155

DO - 10.1073/pnas.84.24.9155

M3 - Article

C2 - 3501122

AN - SCOPUS:0023478699

VL - 84

SP - 9155

EP - 9159

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 24

ER -