Structure and biophysics of CBFβ/ RUNX and its translocation products

Tahir H. Tahirov, John Bushweller

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The core binding factor (CBF) transcription factor is somewhat unique in that it is composed of a DNA binding RUNX subunit (RUNX1, 2, or 3) and a non-DNA binding CBFβ subunit, which modulates RUNX protein activity by modulating the auto-inhibition of the RUNX subunits. Since the discovery of this fascinating transcription factor more than 20 years ago, there has been a robust effort to characterize the structure as well as the biochemical properties of CBF. More recently, these efforts have also extended to the fusion proteins that arise from the subunits of CBF in leukemia. This chapter highlights the work of numerous labs which has provided a detailed understanding of the structure and function of this transcription factor and its fusion proteins.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages21-31
Number of pages11
DOIs
StatePublished - Jan 1 2017

Publication series

NameAdvances in Experimental Medicine and Biology
Volume962
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

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Keywords

  • CBFβ
  • NMR
  • RUNX
  • Structure
  • X-ray

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Tahirov, T. H., & Bushweller, J. (2017). Structure and biophysics of CBFβ/ RUNX and its translocation products. In Advances in Experimental Medicine and Biology (pp. 21-31). (Advances in Experimental Medicine and Biology; Vol. 962). Springer New York LLC. https://doi.org/10.1007/978-981-10-3233-2_2