Structure-activity studies of aldose reductase inhibitors containing the 4-oxo-4H-chromen ring system

Peter F. Kador, Norman E. Sharpless

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Various 4-oxo-4H-chromen-2-carboxylic acids and their derivatives were screened for aldose reductase inhibitory activity. Their inhibitory response along with that of several flavonoids has been correlated with simple Hückel molecular orbital calculations. From these results a possible mode of action is postulated.

Original languageEnglish (US)
Pages (from-to)81-85
Number of pages5
JournalBiophysical Chemistry
Volume8
Issue number1
DOIs
StatePublished - Mar 1978

Fingerprint

Aldehyde Reductase
Orbital calculations
Molecular orbitals
Carboxylic Acids
Flavonoids
carboxylic acids
inhibitors
molecular orbitals
Derivatives
rings

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Organic Chemistry

Cite this

Structure-activity studies of aldose reductase inhibitors containing the 4-oxo-4H-chromen ring system. / Kador, Peter F.; Sharpless, Norman E.

In: Biophysical Chemistry, Vol. 8, No. 1, 03.1978, p. 81-85.

Research output: Contribution to journalArticle

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