Structurally divergent human T cell receptor γ proteins encoded by distinct Cγ genes

Michael S. Krangel, Hamid Band, Shingo Hata, Joanne McLean, Michael B. Brenner

Research output: Contribution to journalArticle

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Abstract

The human T cell receptor (TCR) γ polypeptide occurs in structurally distinct forms on certain peripheral blood T lymphocytes. Complementary DNA clones representing the transcripts of functionally rearranged TCR γ genes in these cells have been analyzed. The expression of a disulfide-linked and a nondisulfide-linked form of TCR γ correlates with the use of the Cγ1 and Cγ2 constant-region gene segments, respectively. Variability in TCR γ polypeptide size and disulfide linkage is determined by the number of copies and the sequence of a repeated segment of the constant region. Thus, Cγ1 and Cγ2 are used to generate structurally distinct, yet functional, T3-associated receptor complexes on peripheral blood lymphocytes. Tryptic peptide mapping suggests that the T3-associated TCR γ and δ peptides in the nondisulfide-linked form are distinct.

Original languageEnglish (US)
Pages (from-to)64-67
Number of pages4
JournalScience
Volume237
Issue number4810
DOIs
StatePublished - Jan 1 1987

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T-Cell Antigen Receptor
Disulfides
Peptides
Genes
Proteins
T-Cell Receptor Genes
Thyroid Hormone Receptors
Peptide Mapping
Complementary DNA
Clone Cells
Lymphocytes
T-Lymphocytes

ASJC Scopus subject areas

  • General

Cite this

Structurally divergent human T cell receptor γ proteins encoded by distinct Cγ genes. / Krangel, Michael S.; Band, Hamid; Hata, Shingo; McLean, Joanne; Brenner, Michael B.

In: Science, Vol. 237, No. 4810, 01.01.1987, p. 64-67.

Research output: Contribution to journalArticle

Krangel, Michael S. ; Band, Hamid ; Hata, Shingo ; McLean, Joanne ; Brenner, Michael B. / Structurally divergent human T cell receptor γ proteins encoded by distinct Cγ genes. In: Science. 1987 ; Vol. 237, No. 4810. pp. 64-67.
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