Structural analysis of chloroquine resistance reversal by imipramine analogs

A. K. Bhattacharjee, D. E. Kyle, J. L. Vennerstrom

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

For imipramine, desipramine, and eight analogs of these well-known drugs, an N-5-aminoalkyl substitution was a minimum but insufficient structural feature associated with chloroquine resistance reversal. Although a second distal aliphatic nitrogen atom was unnecessary for resistance reversal, the direction of the dipole moment vector was critical.

Original languageEnglish (US)
Pages (from-to)2655-2657
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume45
Issue number9
DOIs
StatePublished - Sep 12 2001

Fingerprint

Desipramine
Imipramine
Chloroquine
Nitrogen
Pharmaceutical Preparations
Direction compound

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Structural analysis of chloroquine resistance reversal by imipramine analogs. / Bhattacharjee, A. K.; Kyle, D. E.; Vennerstrom, J. L.

In: Antimicrobial Agents and Chemotherapy, Vol. 45, No. 9, 12.09.2001, p. 2655-2657.

Research output: Contribution to journalArticle

@article{be0fbb6e16b84eb484568d7c51c088ec,
title = "Structural analysis of chloroquine resistance reversal by imipramine analogs",
abstract = "For imipramine, desipramine, and eight analogs of these well-known drugs, an N-5-aminoalkyl substitution was a minimum but insufficient structural feature associated with chloroquine resistance reversal. Although a second distal aliphatic nitrogen atom was unnecessary for resistance reversal, the direction of the dipole moment vector was critical.",
author = "Bhattacharjee, {A. K.} and Kyle, {D. E.} and Vennerstrom, {J. L.}",
year = "2001",
month = "9",
day = "12",
doi = "10.1128/AAC.45.9.2655-2657.2001",
language = "English (US)",
volume = "45",
pages = "2655--2657",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "9",

}

TY - JOUR

T1 - Structural analysis of chloroquine resistance reversal by imipramine analogs

AU - Bhattacharjee, A. K.

AU - Kyle, D. E.

AU - Vennerstrom, J. L.

PY - 2001/9/12

Y1 - 2001/9/12

N2 - For imipramine, desipramine, and eight analogs of these well-known drugs, an N-5-aminoalkyl substitution was a minimum but insufficient structural feature associated with chloroquine resistance reversal. Although a second distal aliphatic nitrogen atom was unnecessary for resistance reversal, the direction of the dipole moment vector was critical.

AB - For imipramine, desipramine, and eight analogs of these well-known drugs, an N-5-aminoalkyl substitution was a minimum but insufficient structural feature associated with chloroquine resistance reversal. Although a second distal aliphatic nitrogen atom was unnecessary for resistance reversal, the direction of the dipole moment vector was critical.

UR - http://www.scopus.com/inward/record.url?scp=0034876783&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034876783&partnerID=8YFLogxK

U2 - 10.1128/AAC.45.9.2655-2657.2001

DO - 10.1128/AAC.45.9.2655-2657.2001

M3 - Article

C2 - 11502547

AN - SCOPUS:0034876783

VL - 45

SP - 2655

EP - 2657

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 9

ER -