Stress resistance and longevity in selected lines of Drosophila melanogaster

Lawrence G Harshman, K. M. Moore, M. A. Sty, M. M. Magwire

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Five independent populations (lines) of Drosophila melanogaster were selected for female starvation resistance. Females and males from the selected lines were relatively starvation resistant when compared to flies from five control lines. Moreover, flies from selected lines were resistant to other stresses: desiccation, acetone fumes, ethanol fumes, and paraquat (a source of oxygen radicals). Data from a variety of previous studies indicate an association between stress resistance and longevity. In this context, the present study addressed the question of whether flies from the stress-resistant lines were relatively long-lived. Replicate population cages from each selected and control line were used to assess longevity. Neither females nor males from the selected lines were relatively long-lived. In at least some cases, stress resistance may be necessary, but not sufficient, for longevity. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)521-529
Number of pages9
JournalNeurobiology of Aging
Volume20
Issue number5
DOIs
StatePublished - Sep 1 1999

Fingerprint

Drosophila melanogaster
Diptera
Starvation
Desiccation
Paraquat
Acetone
Population
Reactive Oxygen Species
Ethanol

Keywords

  • Drosophila melanogaster
  • Longevity
  • Selected lines
  • Selection
  • Stress resistance

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Stress resistance and longevity in selected lines of Drosophila melanogaster. / Harshman, Lawrence G; Moore, K. M.; Sty, M. A.; Magwire, M. M.

In: Neurobiology of Aging, Vol. 20, No. 5, 01.09.1999, p. 521-529.

Research output: Contribution to journalArticle

Harshman, Lawrence G ; Moore, K. M. ; Sty, M. A. ; Magwire, M. M. / Stress resistance and longevity in selected lines of Drosophila melanogaster. In: Neurobiology of Aging. 1999 ; Vol. 20, No. 5. pp. 521-529.
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