Stress-induced cellular transcription factors expressed in trigeminal ganglionic neurons stimulate the herpes simplex virus 1 ICP0 promoter

Devis Sinani, Ethan Cordes, Aspen Workman, Prasanth Thunuguntia, Clinton J Jones

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Alphaherpesvirinae family members can reactivate from latency following stress. The synthetic corticosteroid dexamethasone induces certain cellular transcription factors in murine and bovine trigeminal ganglionic neurons. Three dexamethasone-induced transcription factors, Krüppel-like factor 15, Slug, and SPDEF, stimulated the herpes simplex virus type 1-infected cell protein 0 (ICP0) promoter more than 150-fold. Conversely, other viral promoters (VP16 and ICP4) were not strongly stimulated, suggesting that the ICP0 promoter is preferentially activated by dexamethasone-simulated stress.

Original languageEnglish (US)
Pages (from-to)13042-13047
Number of pages6
JournalJournal of virology
Volume87
Issue number23
DOIs
StatePublished - Dec 1 2013

Fingerprint

Human herpesvirus 1
dexamethasone
Dexamethasone
Transcription Factors
transcription factors
neurons
promoter regions
Neurons
Alphaherpesvirinae
Gastropoda
proteins
slugs
Human Herpesvirus 1
cells
adrenal cortex hormones
Adrenal Cortex Hormones
Proteins
cattle
mice
Human herpesvirus 1 Vmw110 protein

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Stress-induced cellular transcription factors expressed in trigeminal ganglionic neurons stimulate the herpes simplex virus 1 ICP0 promoter. / Sinani, Devis; Cordes, Ethan; Workman, Aspen; Thunuguntia, Prasanth; Jones, Clinton J.

In: Journal of virology, Vol. 87, No. 23, 01.12.2013, p. 13042-13047.

Research output: Contribution to journalArticle

Sinani, Devis ; Cordes, Ethan ; Workman, Aspen ; Thunuguntia, Prasanth ; Jones, Clinton J. / Stress-induced cellular transcription factors expressed in trigeminal ganglionic neurons stimulate the herpes simplex virus 1 ICP0 promoter. In: Journal of virology. 2013 ; Vol. 87, No. 23. pp. 13042-13047.
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