Stress-induced cellular transcription factors expressed in trigeminal ganglionic neurons stimulate the herpes simplex virus 1 ICP0 promoter

Devis Sinani, Ethan Cordes, Aspen Workman, Prasanth Thunuguntia, Clinton Jones

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Alphaherpesvirinae family members can reactivate from latency following stress. The synthetic corticosteroid dexamethasone induces certain cellular transcription factors in murine and bovine trigeminal ganglionic neurons. Three dexamethasone-induced transcription factors, Krüppel-like factor 15, Slug, and SPDEF, stimulated the herpes simplex virus type 1-infected cell protein 0 (ICP0) promoter more than 150-fold. Conversely, other viral promoters (VP16 and ICP4) were not strongly stimulated, suggesting that the ICP0 promoter is preferentially activated by dexamethasone-simulated stress.

Original languageEnglish (US)
Pages (from-to)13042-13047
Number of pages6
JournalJournal of virology
Volume87
Issue number23
DOIs
StatePublished - Dec 1 2013

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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