Strategies to elucidate the mechanism of excessive theca cell androgen production in PCOS

Jerome F. Strauss, Jennifer R. Wood, Lane K. Christenson, Jan M. McAllister

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Polycystic ovary syndrome (PCOS) is characterized by increased ovarian androgen production. We have developed a strategy to identify differentially transcribed genes in PCOS theca cells. Using long-term cultures of normal and PCOS theca cells, we are characterizing the complete repertoire of differentially transcribed genes, the common transcription factor mediators, and the signal transduction cascade(s) that are abnormal in PCOS theca cells. The latter will be interrogated for mutations/genetic variants linked to PCOS.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalMolecular and Cellular Endocrinology
Volume186
Issue number2
DOIs
StatePublished - Jan 25 2002

Fingerprint

Theca Cells
Polycystic Ovary Syndrome
Androgens
Genes
Signal transduction
Transcription Factors
Signal Transduction
Mutation

Keywords

  • Androgen biosynthesis
  • Chromatin immunoprecipitation
  • Polycystic ovary syndrome
  • Suppression subtractive hybridization

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Cite this

Strategies to elucidate the mechanism of excessive theca cell androgen production in PCOS. / Strauss, Jerome F.; Wood, Jennifer R.; Christenson, Lane K.; McAllister, Jan M.

In: Molecular and Cellular Endocrinology, Vol. 186, No. 2, 25.01.2002, p. 183-188.

Research output: Contribution to journalArticle

Strauss, Jerome F. ; Wood, Jennifer R. ; Christenson, Lane K. ; McAllister, Jan M. / Strategies to elucidate the mechanism of excessive theca cell androgen production in PCOS. In: Molecular and Cellular Endocrinology. 2002 ; Vol. 186, No. 2. pp. 183-188.
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