Strategies for Studying the Regulation of B Lymphocytes by Prostaglandin E2

Melinda A. Borrello, Eric R. Fedyk, Deborah M. Brown, Richard P. Phipps

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The widely held view that prostaglandin E2 (PGE2) only down-regulates immune function has been challenged by recent data from this and other laboratories. In the case of B lymphocytes, PGE2 has potent regulatory effects on activation and immunoglobulin class switching. Furthermore, the maturation stage at which a B cell encounters PGE2 can determine whether the lymphocyte continues along its differentiative path or is terminated by apoptosis. Our studies have combined the use of murine B lymphomas and normal B lymphocytes to unravel the mechanisms by which PGE2 affects B cells. Here we describe the strategies and approaches that have led to a new understanding of PGE2 regulation of immunity. These models may be extended to the study of other prostanoids and to human B lymphocytes.

Original languageEnglish (US)
Pages (from-to)261-272
Number of pages12
JournalImmunoMethods
Volume2
Issue number3
DOIs
StatePublished - Jun 1 1993

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Lymphocytes
Dinoprostone
B-Lymphocytes
Cells
Immunoglobulin Class Switching
Immunoglobulin Isotypes
Prostaglandins
Immunity
Lymphoma
Down-Regulation
Chemical activation
Apoptosis

ASJC Scopus subject areas

  • Immunology

Cite this

Strategies for Studying the Regulation of B Lymphocytes by Prostaglandin E2. / Borrello, Melinda A.; Fedyk, Eric R.; Brown, Deborah M.; Phipps, Richard P.

In: ImmunoMethods, Vol. 2, No. 3, 01.06.1993, p. 261-272.

Research output: Contribution to journalArticle

Borrello, Melinda A. ; Fedyk, Eric R. ; Brown, Deborah M. ; Phipps, Richard P. / Strategies for Studying the Regulation of B Lymphocytes by Prostaglandin E2. In: ImmunoMethods. 1993 ; Vol. 2, No. 3. pp. 261-272.
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