Stereostructure-activity relationships of the GABA-containing cis-decahydroquinoline-5-carboxylic acids; Intracerebroventricular studies in mice

Y. K. Fung, C. Bero, D. Dircks, K. Tomita, R. J. Patch, D. T. Witiak

Research output: Contribution to journalArticle

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Abstract

Two cis-decahydroquinoline-5-carboxylic acids, cis-1 and 2 were investigated for their pharmacological activities in vivo. Intracerebroventricular administration of either agent elicited convulsant activity in mice. This convulsant effect can be antagonized by pretreating the mice with n-dipropylacetate (valproate). Our results suggest that cis-1 may act indirectly as a partial γ-aminobutyric acid (GABA) agonist in vivo. On the other hand, both cis-1 and 2, at higher concentrations, exhibit properties of a GABA-antagonist, but this effect seems not to be due to GABA receptor binding.

Original languageEnglish (US)
Pages (from-to)367-380
Number of pages14
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume39
Issue number3
Publication statusPublished - Jun 2 1983

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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