Stem cells: A revolution in therapeutics - Recent advances in stem cell biology and their therapeutic applications in regenerative medicine and cancer therapies

M. Mimeault, R. Hauke, Surinder Kumar Batra

Research output: Contribution to journalReview article

298 Citations (Scopus)

Abstract

Basic and clinical research accomplished during the last few years on embryonic, fetal, amniotic, umbilical cord blood, and adult stem cells has constituted a revolution in regenerative medicine and cancer therapies by providing the possibility of generating multiple therapeutically useful cell types. These new cells could be used for treating numerous genetic and degenerative disorders. Among them, age-related functional defects, hematopoietic and immune system disorders, heart failures, chronic liver injuries, diabetes, Parkinson's and Alzheimer's diseases, arthritis, and muscular, skin, lung, eye, and digestive disorders as well as aggressive and recurrent cancers could be successfully treated by stem cell-based therapies. This review focuses on the recent advancements in adult stem cell biology in normal and pathological conditions. We describe how these results have improved our understanding on critical and unique functions of these rare sub-populations of multipotent and undifferentiated cells with an unlimited self-renewal capacity and high plasticity. Finally, we discuss some major advances to translate the experimental models on ex vivo and in vivo expanded and/or differentiated stem cells into clinical applications for the development of novel cellular therapies aimed at repairing genetically altered or damaged tissues/organs in humans. A particular emphasis is made on the therapeutic potential of different tissue-resident adult stem cell types and their in vivo modulation for treating and curing specific pathological disorders.

Original languageEnglish (US)
Pages (from-to)252-264
Number of pages13
JournalClinical Pharmacology and Therapeutics
Volume82
Issue number3
DOIs
StatePublished - Sep 1 2007

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Adult Stem Cells
Regenerative Medicine
Cell Biology
Stem Cells
Hematopoietic System
Neoplasms
Inborn Genetic Diseases
Immune System Diseases
Cell- and Tissue-Based Therapy
Fetal Blood
Arthritis
Parkinson Disease
Immune System
Alzheimer Disease
Theoretical Models
Therapeutics
Heart Failure
Lung
Skin
Liver

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

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