Stem cell technology for neurodegenerative diseases

J. Simon Lunn, Stacey A. Sakowski, Junguk Hur, Eva L. Feldman

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Over the past 20 years, stem cell technologies have become an increasingly attractive option to investigate and treat neurodegenerative diseases. In the current review, we discuss the process of extending basic stem cell research into translational therapies for patients suffering from neurodegenerative diseases. We begin with a discussion of the burden of these diseases on society, emphasizing the need for increased attention toward advancing stem cell therapies. We then explain the various types of stem cells utilized in neurodegenerative disease research, and outline important issues to consider in the transition of stem cell therapy from bench to bedside. Finally, we detail the current progress regarding the applications of stem cell therapies to specific neurodegenerative diseases, focusing on Parkinson disease, Huntington disease, Alzheimer disease, amyotrophic lateral sclerosis, and spinal muscular atrophy. With a greater understanding of the capacity of stem cell technologies, there is growing public hope that stem cell therapies will continue to progress into realistic and efficacious treatments for neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)353-361
Number of pages9
JournalAnnals of Neurology
Volume70
Issue number3
DOIs
StatePublished - Sep 1 2011

Fingerprint

Neurodegenerative Diseases
Stem Cells
Technology
Cell- and Tissue-Based Therapy
Stem Cell Research
Spinal Muscular Atrophy
Huntington Disease
Amyotrophic Lateral Sclerosis
Parkinson Disease
Alzheimer Disease
Therapeutics
Research

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Lunn, J. S., Sakowski, S. A., Hur, J., & Feldman, E. L. (2011). Stem cell technology for neurodegenerative diseases. Annals of Neurology, 70(3), 353-361. https://doi.org/10.1002/ana.22487

Stem cell technology for neurodegenerative diseases. / Lunn, J. Simon; Sakowski, Stacey A.; Hur, Junguk; Feldman, Eva L.

In: Annals of Neurology, Vol. 70, No. 3, 01.09.2011, p. 353-361.

Research output: Contribution to journalArticle

Lunn, JS, Sakowski, SA, Hur, J & Feldman, EL 2011, 'Stem cell technology for neurodegenerative diseases', Annals of Neurology, vol. 70, no. 3, pp. 353-361. https://doi.org/10.1002/ana.22487
Lunn, J. Simon ; Sakowski, Stacey A. ; Hur, Junguk ; Feldman, Eva L. / Stem cell technology for neurodegenerative diseases. In: Annals of Neurology. 2011 ; Vol. 70, No. 3. pp. 353-361.
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