Status of Vitamin A and Related Compounds and Clinical Outcomes in Maternal-Infant Pairs in the Midwestern United States

Corrine K Hanson, Marina Schumacher, Elizabeth Lyden, Jeremy Furtado, Matthew Van Ormer, Elizabeth McGinn, Katherine Rilett, Caleb Cave, Rebecca Johnson, Kara Weishaar, Ann L Anderson Berry

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Vitamin A is an essential nutrient for pregnant women, and other Vitamin A-related compounds, including lutein and lycopene, have been associated with maternal-infant outcomes. The objective of this study was to quantify the status of Vitamin A and related compounds in maternal-infant pairs at the time of delivery, and to determine its impact on clinical outcomes. Methods: Maternal and cord blood samples were collected in 189 mother-infant pairs. Concentrations of lutein + zeaxanthin, β-cryptoxanthin, lycopene, carotenes, and retinol were measured using high-performance liquid chromatography. Descriptive statistics was calculated and Spearman coefficients were used to assess correlations between maternal and cord measurements. Kruskal-Wallis and independent samples t test were used to compare measures between retinol groups. Linear and logistic regression models were used to adjust for relevant confounders. p < 0.05 was considered statistically significant. Results: Ten percent of mothers had serum retinol concentrations ≤0.70 μmol/L; 80% of infants had serum retinol concentrations ≤0.70 μmol/L. Low maternal retinol concentrations were associated with maternal anemia (p = 0.04) and a trend toward low birth weight (p = 0.06). Maternal and infant concentrations of Vitamin A compounds were highly correlated. After adjustment for confounders, maternal lutein was associated with a C-section (p = 0.03) and a diagnosis of respiratory distress syndrome in the infant (p = 0.02). Maternal lycopene was associated with growth parameters in the infant. Conclusions: As Vitamin A-related compounds are modifiable by diet, future research determining the clinical impact of these compounds is warranted.

Original languageEnglish (US)
Pages (from-to)175-182
Number of pages8
JournalAnnals of Nutrition and Metabolism
Volume71
Issue number3-4
DOIs
StatePublished - Jan 1 2018

Fingerprint

Midwestern United States
Vitamin A
Mothers
Lutein
Logistic Models
Newborn Respiratory Distress Syndrome
Low Birth Weight Infant
Carotenoids
Serum
Fetal Blood
Anemia
Pregnant Women
Linear Models

Keywords

  • Lutein
  • Lycopene
  • Newborn
  • Pregnancy
  • Vitamin A

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Status of Vitamin A and Related Compounds and Clinical Outcomes in Maternal-Infant Pairs in the Midwestern United States. / Hanson, Corrine K; Schumacher, Marina; Lyden, Elizabeth; Furtado, Jeremy; Van Ormer, Matthew; McGinn, Elizabeth; Rilett, Katherine; Cave, Caleb; Johnson, Rebecca; Weishaar, Kara; Anderson Berry, Ann L.

In: Annals of Nutrition and Metabolism, Vol. 71, No. 3-4, 01.01.2018, p. 175-182.

Research output: Contribution to journalArticle

Hanson, CK, Schumacher, M, Lyden, E, Furtado, J, Van Ormer, M, McGinn, E, Rilett, K, Cave, C, Johnson, R, Weishaar, K & Anderson Berry, AL 2018, 'Status of Vitamin A and Related Compounds and Clinical Outcomes in Maternal-Infant Pairs in the Midwestern United States', Annals of Nutrition and Metabolism, vol. 71, no. 3-4, pp. 175-182. https://doi.org/10.1159/000481292
Hanson, Corrine K ; Schumacher, Marina ; Lyden, Elizabeth ; Furtado, Jeremy ; Van Ormer, Matthew ; McGinn, Elizabeth ; Rilett, Katherine ; Cave, Caleb ; Johnson, Rebecca ; Weishaar, Kara ; Anderson Berry, Ann L. / Status of Vitamin A and Related Compounds and Clinical Outcomes in Maternal-Infant Pairs in the Midwestern United States. In: Annals of Nutrition and Metabolism. 2018 ; Vol. 71, No. 3-4. pp. 175-182.
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T1 - Status of Vitamin A and Related Compounds and Clinical Outcomes in Maternal-Infant Pairs in the Midwestern United States

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AU - Schumacher, Marina

AU - Lyden, Elizabeth

AU - Furtado, Jeremy

AU - Van Ormer, Matthew

AU - McGinn, Elizabeth

AU - Rilett, Katherine

AU - Cave, Caleb

AU - Johnson, Rebecca

AU - Weishaar, Kara

AU - Anderson Berry, Ann L

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N2 - Background: Vitamin A is an essential nutrient for pregnant women, and other Vitamin A-related compounds, including lutein and lycopene, have been associated with maternal-infant outcomes. The objective of this study was to quantify the status of Vitamin A and related compounds in maternal-infant pairs at the time of delivery, and to determine its impact on clinical outcomes. Methods: Maternal and cord blood samples were collected in 189 mother-infant pairs. Concentrations of lutein + zeaxanthin, β-cryptoxanthin, lycopene, carotenes, and retinol were measured using high-performance liquid chromatography. Descriptive statistics was calculated and Spearman coefficients were used to assess correlations between maternal and cord measurements. Kruskal-Wallis and independent samples t test were used to compare measures between retinol groups. Linear and logistic regression models were used to adjust for relevant confounders. p < 0.05 was considered statistically significant. Results: Ten percent of mothers had serum retinol concentrations ≤0.70 μmol/L; 80% of infants had serum retinol concentrations ≤0.70 μmol/L. Low maternal retinol concentrations were associated with maternal anemia (p = 0.04) and a trend toward low birth weight (p = 0.06). Maternal and infant concentrations of Vitamin A compounds were highly correlated. After adjustment for confounders, maternal lutein was associated with a C-section (p = 0.03) and a diagnosis of respiratory distress syndrome in the infant (p = 0.02). Maternal lycopene was associated with growth parameters in the infant. Conclusions: As Vitamin A-related compounds are modifiable by diet, future research determining the clinical impact of these compounds is warranted.

AB - Background: Vitamin A is an essential nutrient for pregnant women, and other Vitamin A-related compounds, including lutein and lycopene, have been associated with maternal-infant outcomes. The objective of this study was to quantify the status of Vitamin A and related compounds in maternal-infant pairs at the time of delivery, and to determine its impact on clinical outcomes. Methods: Maternal and cord blood samples were collected in 189 mother-infant pairs. Concentrations of lutein + zeaxanthin, β-cryptoxanthin, lycopene, carotenes, and retinol were measured using high-performance liquid chromatography. Descriptive statistics was calculated and Spearman coefficients were used to assess correlations between maternal and cord measurements. Kruskal-Wallis and independent samples t test were used to compare measures between retinol groups. Linear and logistic regression models were used to adjust for relevant confounders. p < 0.05 was considered statistically significant. Results: Ten percent of mothers had serum retinol concentrations ≤0.70 μmol/L; 80% of infants had serum retinol concentrations ≤0.70 μmol/L. Low maternal retinol concentrations were associated with maternal anemia (p = 0.04) and a trend toward low birth weight (p = 0.06). Maternal and infant concentrations of Vitamin A compounds were highly correlated. After adjustment for confounders, maternal lutein was associated with a C-section (p = 0.03) and a diagnosis of respiratory distress syndrome in the infant (p = 0.02). Maternal lycopene was associated with growth parameters in the infant. Conclusions: As Vitamin A-related compounds are modifiable by diet, future research determining the clinical impact of these compounds is warranted.

KW - Lutein

KW - Lycopene

KW - Newborn

KW - Pregnancy

KW - Vitamin A

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