Status of retinoids and carotenoids and associations with clinical outcomes in maternal-infant pairs in Nigeria

Corrine K Hanson, Elizabeth Lyden, Ann L Anderson Berry, Nicholas Kocmich, Amy Rezac, Shirley Delair, Jeremy Furtado, Matthew Van Ormer, N. I. Izevbigie, E. D. Olateju, G. A. Adaba, E. A. Anigilaje, Tahiru Tahiru, Stephen K Obaro

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Vitamin A is an essential nutrient in pregnancy, and other carotenoids have been independently associated with maternal-infant outcomes. The objective of this study was to quantify the status of vitamin A and carotenoids in Nigerian maternal-infant pairs at delivery, compare these to a cohort from a developed nation, and determine the impact on clinical outcomes. Maternal and cord blood samples were collected in 99 Nigerian mother-infant pairs. Concentrations of lutein + zeaxanthin, β-cryptoxanthin, lycopene, α- and β-carotenes, and retinol were measured using HPLC. Descriptive statistics were calculated and Spearman coefficients were used to assess correlations between maternal and cord measurements; Mann-Whitney tests were used to compare median plasma values between dichotomous variables. Linear regression models were used to adjust for relevant confounders. A p < 0.05 was considered statistically significant. Thirty-five percent of mothers had plasma retinol concentrations ≤0.70 µmol/L; 82% of infants had plasma retinol concentrations ≤0.70 µmol/L at delivery. Maternal and infant concentrations of vitamin A compounds were highly correlated and were associated with newborn growth and Apgar scores. Despite plasma concentrations of pro-vitamin A carotenoids higher than those reported in other populations, pregnant Nigerian women have a high prevalence of vitamin A deficiency. As vitamin A related compounds are modifiable by diet, future research determining the clinical impact of these compounds is warranted.

Original languageEnglish (US)
Article number1286
JournalNutrients
Volume10
Issue number9
DOIs
StatePublished - Sep 12 2018

Fingerprint

retinoids
Retinoids
Carotenoids
Nigeria
Vitamin A
vitamin A
carotenoids
Mothers
carotenes
Linear Models
vitamin A deficiency
Vitamin A Deficiency
Lutein
zeaxanthin
lycopene
Apgar Score
lutein
developed countries
Fetal Blood
Developed Countries

Keywords

  • Carotenoids
  • Lutein
  • Maternal-child
  • Pregnancy
  • Vitamin A
  • β-carotene

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Status of retinoids and carotenoids and associations with clinical outcomes in maternal-infant pairs in Nigeria. / Hanson, Corrine K; Lyden, Elizabeth; Anderson Berry, Ann L; Kocmich, Nicholas; Rezac, Amy; Delair, Shirley; Furtado, Jeremy; Van Ormer, Matthew; Izevbigie, N. I.; Olateju, E. D.; Adaba, G. A.; Anigilaje, E. A.; Tahiru, Tahiru; Obaro, Stephen K.

In: Nutrients, Vol. 10, No. 9, 1286, 12.09.2018.

Research output: Contribution to journalArticle

Hanson, CK, Lyden, E, Anderson Berry, AL, Kocmich, N, Rezac, A, Delair, S, Furtado, J, Van Ormer, M, Izevbigie, NI, Olateju, ED, Adaba, GA, Anigilaje, EA, Tahiru, T & Obaro, SK 2018, 'Status of retinoids and carotenoids and associations with clinical outcomes in maternal-infant pairs in Nigeria', Nutrients, vol. 10, no. 9, 1286. https://doi.org/10.3390/nu10091286
Hanson, Corrine K ; Lyden, Elizabeth ; Anderson Berry, Ann L ; Kocmich, Nicholas ; Rezac, Amy ; Delair, Shirley ; Furtado, Jeremy ; Van Ormer, Matthew ; Izevbigie, N. I. ; Olateju, E. D. ; Adaba, G. A. ; Anigilaje, E. A. ; Tahiru, Tahiru ; Obaro, Stephen K. / Status of retinoids and carotenoids and associations with clinical outcomes in maternal-infant pairs in Nigeria. In: Nutrients. 2018 ; Vol. 10, No. 9.
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