Statins use and risk for brain metastasis from lung cancer

D. Leigh, J. Eken, J. R. Beal, Apar Kishor P Ganti, A. E. Sahmoun

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Laboratory data suggest an association between statins and risk of brain metastasis (BM) in patients diagnosed with lung cancer. Our retrospective cohort included 252 patients diagnosed with lung cancer and 55 (22) patients subsequently developed BM. The risk of BM was significantly higher in younger patients (p < .0007). The multivariable Cox model did not show a significant association between statin use and BM from lung cancer (Hazard-Ratio (HR) 1.20, 95 confidence interval (CI): 0.682.13). Future studies should focus on late stage NSCLC and examine the incidence of BM among statin users at the time of death.

Original languageEnglish (US)
Pages (from-to)68-72
Number of pages5
JournalCancer Investigation
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2011

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Lung Neoplasms
Neoplasm Metastasis
Brain
Proportional Hazards Models
Confidence Intervals
Incidence

Keywords

  • Brain metastasis
  • Cohort
  • Epidemiology
  • Hydrophobic
  • Lung cancer
  • Statins

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Statins use and risk for brain metastasis from lung cancer. / Leigh, D.; Eken, J.; Beal, J. R.; Ganti, Apar Kishor P; Sahmoun, A. E.

In: Cancer Investigation, Vol. 29, No. 1, 01.01.2011, p. 68-72.

Research output: Contribution to journalArticle

Leigh, D. ; Eken, J. ; Beal, J. R. ; Ganti, Apar Kishor P ; Sahmoun, A. E. / Statins use and risk for brain metastasis from lung cancer. In: Cancer Investigation. 2011 ; Vol. 29, No. 1. pp. 68-72.
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