STAT3 acts as a co-activator of glucocorticoid receptor signaling

Zhixin Zhang, Simon Jones, James S. Hagood, Nelson L. Fuentes, Gerald M. Fuller

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

Interleukin-6 (IL-6) and glucocorticoids are important mediators of inflammatory and immunological responses. Glucocorticoids are known to synergistically enhance IL-6-mediated cellular responses. We now show that IL-6 also has a synergistic effect upon glucocorticoid signaling. In particular, IL-6-activated STAT3 associates with ligand-bound glucocorticoid receptor to form a transactivating/signaling complex, which can function through either an IL-6-responsive element or a glucocorticoid-responsive element. These findings reveal a new level of interaction between these two crucial signaling cascades and indicate that activated STAT3 can also act as a transcriptional co-activator without direct association with its DNA binding motif.

Original languageEnglish (US)
Pages (from-to)30607-30610
Number of pages4
JournalJournal of Biological Chemistry
Volume272
Issue number49
DOIs
StatePublished - Dec 5 1997

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Glucocorticoid Receptors
Interleukin-6
Glucocorticoids
Nucleotide Motifs
Ligands
DNA

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Zhang, Z., Jones, S., Hagood, J. S., Fuentes, N. L., & Fuller, G. M. (1997). STAT3 acts as a co-activator of glucocorticoid receptor signaling. Journal of Biological Chemistry, 272(49), 30607-30610. https://doi.org/10.1074/jbc.272.49.30607

STAT3 acts as a co-activator of glucocorticoid receptor signaling. / Zhang, Zhixin; Jones, Simon; Hagood, James S.; Fuentes, Nelson L.; Fuller, Gerald M.

In: Journal of Biological Chemistry, Vol. 272, No. 49, 05.12.1997, p. 30607-30610.

Research output: Contribution to journalArticle

Zhang, Z, Jones, S, Hagood, JS, Fuentes, NL & Fuller, GM 1997, 'STAT3 acts as a co-activator of glucocorticoid receptor signaling', Journal of Biological Chemistry, vol. 272, no. 49, pp. 30607-30610. https://doi.org/10.1074/jbc.272.49.30607
Zhang, Zhixin ; Jones, Simon ; Hagood, James S. ; Fuentes, Nelson L. ; Fuller, Gerald M. / STAT3 acts as a co-activator of glucocorticoid receptor signaling. In: Journal of Biological Chemistry. 1997 ; Vol. 272, No. 49. pp. 30607-30610.
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