Staphylococcus aureus biofilm: a complex developmental organism

Derek E. Moormeier, Kenneth W Bayles

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

Chronic biofilm-associated infections caused by Staphylococcus aureus often lead to significant increases in morbidity and mortality, particularly when associated with indwelling medical devices. This has triggered a great deal of research attempting to understand the molecular mechanisms that control S. aureus biofilm formation and the basis for the recalcitrance of these multicellular structures to antibiotic therapy. The purpose of this review is to summarize our current understanding of S. aureus biofilm development, focusing on the description of a newly-defined, five-stage model of biofilm development and the mechanisms required for each stage. Importantly, this model includes an alternate view of the processes involved in microcolony formation in S. aureus and suggests that these structures originate as a result of stochastically regulated metabolic heterogeneity and proliferation within a maturing biofilm population, rather than a subtractive process involving the release of cell clusters from a thick, unstructured biofilm. Importantly, it is proposed that this new model of biofilm development involves the genetically programmed generation of metabolically distinct subpopulations of cells, resulting in an overall population that is better able to adapt to rapidly changing environmental conditions.

Original languageEnglish (US)
Pages (from-to)365-376
Number of pages12
JournalMolecular Microbiology
Volume104
Issue number3
DOIs
StatePublished - May 2017

Fingerprint

Biofilms
Staphylococcus aureus
Population
Anti-Bacterial Agents
Morbidity
Equipment and Supplies
Mortality
Infection
Research

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Cite this

Staphylococcus aureus biofilm : a complex developmental organism. / Moormeier, Derek E.; Bayles, Kenneth W.

In: Molecular Microbiology, Vol. 104, No. 3, 05.2017, p. 365-376.

Research output: Contribution to journalReview article

@article{62f7e11d2fe345729e70faa49d3bfd3f,
title = "Staphylococcus aureus biofilm: a complex developmental organism",
abstract = "Chronic biofilm-associated infections caused by Staphylococcus aureus often lead to significant increases in morbidity and mortality, particularly when associated with indwelling medical devices. This has triggered a great deal of research attempting to understand the molecular mechanisms that control S. aureus biofilm formation and the basis for the recalcitrance of these multicellular structures to antibiotic therapy. The purpose of this review is to summarize our current understanding of S. aureus biofilm development, focusing on the description of a newly-defined, five-stage model of biofilm development and the mechanisms required for each stage. Importantly, this model includes an alternate view of the processes involved in microcolony formation in S. aureus and suggests that these structures originate as a result of stochastically regulated metabolic heterogeneity and proliferation within a maturing biofilm population, rather than a subtractive process involving the release of cell clusters from a thick, unstructured biofilm. Importantly, it is proposed that this new model of biofilm development involves the genetically programmed generation of metabolically distinct subpopulations of cells, resulting in an overall population that is better able to adapt to rapidly changing environmental conditions.",
author = "Moormeier, {Derek E.} and Bayles, {Kenneth W}",
year = "2017",
month = "5",
doi = "10.1111/mmi.13634",
language = "English (US)",
volume = "104",
pages = "365--376",
journal = "Molecular Microbiology",
issn = "0950-382X",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Staphylococcus aureus biofilm

T2 - a complex developmental organism

AU - Moormeier, Derek E.

AU - Bayles, Kenneth W

PY - 2017/5

Y1 - 2017/5

N2 - Chronic biofilm-associated infections caused by Staphylococcus aureus often lead to significant increases in morbidity and mortality, particularly when associated with indwelling medical devices. This has triggered a great deal of research attempting to understand the molecular mechanisms that control S. aureus biofilm formation and the basis for the recalcitrance of these multicellular structures to antibiotic therapy. The purpose of this review is to summarize our current understanding of S. aureus biofilm development, focusing on the description of a newly-defined, five-stage model of biofilm development and the mechanisms required for each stage. Importantly, this model includes an alternate view of the processes involved in microcolony formation in S. aureus and suggests that these structures originate as a result of stochastically regulated metabolic heterogeneity and proliferation within a maturing biofilm population, rather than a subtractive process involving the release of cell clusters from a thick, unstructured biofilm. Importantly, it is proposed that this new model of biofilm development involves the genetically programmed generation of metabolically distinct subpopulations of cells, resulting in an overall population that is better able to adapt to rapidly changing environmental conditions.

AB - Chronic biofilm-associated infections caused by Staphylococcus aureus often lead to significant increases in morbidity and mortality, particularly when associated with indwelling medical devices. This has triggered a great deal of research attempting to understand the molecular mechanisms that control S. aureus biofilm formation and the basis for the recalcitrance of these multicellular structures to antibiotic therapy. The purpose of this review is to summarize our current understanding of S. aureus biofilm development, focusing on the description of a newly-defined, five-stage model of biofilm development and the mechanisms required for each stage. Importantly, this model includes an alternate view of the processes involved in microcolony formation in S. aureus and suggests that these structures originate as a result of stochastically regulated metabolic heterogeneity and proliferation within a maturing biofilm population, rather than a subtractive process involving the release of cell clusters from a thick, unstructured biofilm. Importantly, it is proposed that this new model of biofilm development involves the genetically programmed generation of metabolically distinct subpopulations of cells, resulting in an overall population that is better able to adapt to rapidly changing environmental conditions.

UR - http://www.scopus.com/inward/record.url?scp=85014675754&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014675754&partnerID=8YFLogxK

U2 - 10.1111/mmi.13634

DO - 10.1111/mmi.13634

M3 - Review article

C2 - 28142193

AN - SCOPUS:85014675754

VL - 104

SP - 365

EP - 376

JO - Molecular Microbiology

JF - Molecular Microbiology

SN - 0950-382X

IS - 3

ER -