Staphylococcus aureus

J. L. Bose, K. W. Bayles

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Staphylococcus aureus is an important pathogen that has a major impact on human health. Although it is notorious for causing skin and soft-tissue infections, it has the ability to infect nearly every organ system in the human body, often with fatal consequences. This remarkable adaptability is due in large part to the wide array of virulence factors it produces, many of which are encoded on plasmids, transposons, prophage, and pathogenicity islands. While these elements are important for genetic exchange in the environment, they have also been exploited to create genetic tools for manipulating this bacterium. These tools allow for the construction of defined chromosomal mutations, transposon insertion libraries, and protein expression systems that have greatly enhanced our understanding of staphylococcal pathogenesis.

Original languageEnglish (US)
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages553-555
Number of pages3
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
DOIs
StatePublished - Feb 27 2013

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Keywords

  • Bacteria
  • Genetics
  • Gram-positive
  • MRSA
  • Mutation
  • Plasmid
  • Transduction
  • Transposon

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Bose, J. L., & Bayles, K. W. (2013). Staphylococcus aureus. In Brenner's Encyclopedia of Genetics: Second Edition (pp. 553-555). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374984-0.01473-X