Staphylococcal enterotoxin is a bovine t cell superantigen

Robert Schmaltz, Balbir Bhogal, Yan Yu Wang, Thomas M Petro, Swey Shen Chen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Different isoforms of soluble staphylococcal enterotoxins (SE): SEB, SEC-1 and SEC-2, were shown to stimulate bovine T cell proliferation, expression of cytokine messages, and IgG production. Intact metabolic function of APC was not required since peripheral blood mononuclear cells (PBMC), UV-irradiated prior to or following incubation with SE, were both capable of presenting SE, while PBMC treated with MAbs against MHC II lost the ability to stimulate T cell proliferation. SE caused approximately two fold increase of CD4+, and CD8+ T cells, but not MHC II+ APC or B cells. This model system suggests that SE transduces not only T cell activation signal, but also a non-proliferative signal for primary B cells to produce polyclonal IgG. We hypothesize that enterotoxin virulence may be in part due to its effect on activating the immune system.

Original languageEnglish (US)
Pages (from-to)805-818
Number of pages14
JournalImmunological Investigations
Volume24
Issue number5
DOIs
StatePublished - Jan 1 1995

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Superantigens
Enterotoxins
T-Lymphocytes
Blood Cells
B-Lymphocytes
Immunoglobulin G
Cell Proliferation
Virulence
Immune System
Protein Isoforms
Cytokines

ASJC Scopus subject areas

  • Immunology

Cite this

Staphylococcal enterotoxin is a bovine t cell superantigen. / Schmaltz, Robert; Bhogal, Balbir; Wang, Yan Yu; Petro, Thomas M; Chen, Swey Shen.

In: Immunological Investigations, Vol. 24, No. 5, 01.01.1995, p. 805-818.

Research output: Contribution to journalArticle

Schmaltz, Robert ; Bhogal, Balbir ; Wang, Yan Yu ; Petro, Thomas M ; Chen, Swey Shen. / Staphylococcal enterotoxin is a bovine t cell superantigen. In: Immunological Investigations. 1995 ; Vol. 24, No. 5. pp. 805-818.
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