Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome

María X. Maldonado-Gómez, Inés Martínez, Francesca Bottacini, Amy O'Callaghan, Marco Ventura, Douwe van Sinderen, Benjamin Hillmann, Pajau Vangay, Dan Knights, Robert W. Hutkins, Jens Walter

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Live bacteria (such as probiotics) have long been used to modulate gut microbiota and human physiology, but their colonization is mostly transient. Conceptual understanding of the ecological principles as they apply to exogenously introduced microbes in gut ecosystems is lacking. We find that, when orally administered to humans, Bifidobacterium longum AH1206 stably persists in the gut of 30% of individuals for at least 6 months without causing gastrointestinal symptoms or impacting the composition of the resident gut microbiota. AH1206 engraftment was associated with low abundance of resident B. longum and underrepresentation of specific carbohydrate utilization genes in the pre-treatment microbiome. Thus, phylogenetic limiting and resource availability are two factors that control the niche opportunity for AH1206 colonization. These findings suggest that bacterial species and functional genes absent in the gut microbiome of individual humans can be reestablished, providing opportunities for precise and personalized microbiome reconstitution.

Original languageEnglish (US)
Pages (from-to)515-526
Number of pages12
JournalCell Host and Microbe
Volume20
Issue number4
DOIs
StatePublished - Oct 12 2016

Fingerprint

Microbiota
Probiotics
Genes
Ecosystem
Carbohydrates
Bacteria
Gastrointestinal Microbiome
Bifidobacterium longum

Keywords

  • Bifidobacterium
  • ecological theory
  • gut microbiome
  • gut microbiota
  • invasion ecology
  • live biotherapeutic
  • metagenomics
  • microbial ecology
  • microbiome modulation
  • probiotic

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

Cite this

Maldonado-Gómez, M. X., Martínez, I., Bottacini, F., O'Callaghan, A., Ventura, M., van Sinderen, D., ... Walter, J. (2016). Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome. Cell Host and Microbe, 20(4), 515-526. https://doi.org/10.1016/j.chom.2016.09.001

Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome. / Maldonado-Gómez, María X.; Martínez, Inés; Bottacini, Francesca; O'Callaghan, Amy; Ventura, Marco; van Sinderen, Douwe; Hillmann, Benjamin; Vangay, Pajau; Knights, Dan; Hutkins, Robert W.; Walter, Jens.

In: Cell Host and Microbe, Vol. 20, No. 4, 12.10.2016, p. 515-526.

Research output: Contribution to journalArticle

Maldonado-Gómez, MX, Martínez, I, Bottacini, F, O'Callaghan, A, Ventura, M, van Sinderen, D, Hillmann, B, Vangay, P, Knights, D, Hutkins, RW & Walter, J 2016, 'Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome', Cell Host and Microbe, vol. 20, no. 4, pp. 515-526. https://doi.org/10.1016/j.chom.2016.09.001
Maldonado-Gómez, María X. ; Martínez, Inés ; Bottacini, Francesca ; O'Callaghan, Amy ; Ventura, Marco ; van Sinderen, Douwe ; Hillmann, Benjamin ; Vangay, Pajau ; Knights, Dan ; Hutkins, Robert W. ; Walter, Jens. / Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome. In: Cell Host and Microbe. 2016 ; Vol. 20, No. 4. pp. 515-526.
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