Stability of suspension formulations of lansoprazole and omeprazole stored in amber-colored plastic oral syringes

Jennifer L. DiGiacinto, Keith Melvin Olsen, Kimberly L. Bergman, Eric B. Hoie

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

OBJECTIVE: To determine the stability of lansoprazole and omeprazole suspensions at ambient and refrigerated temperatures using HPLC. DESIGN: The contents of lansoprazole and omeprazole capsules were suspended in separate flasks containing sodium bicarbonate 8.4% to concentrations of 3 and 2 mg/mL, respectively. The contents of each flask were drawn into six amber-colored oral syringes, with one-half of the syringes stored at 22 °C (ambient) and the other half at 4 °C. Lansoprazole and omeprazole concentrations were determined by a stability-indicating HPLC assay at baseline and at 4, 8, 12, and 24 hours, and on days 4, 7, 14, 21, 30, 45, and 60 after mixing. Both omeprazole and lansoprazole were considered stable if they retained ≥90% of the baseline drug concentration. RESULTS: Omeprazole was stable for up to 14 days at 22 °C and 45 days at 4 °C. Lansoprazole was stable for eight hours at 22 °C and for 14 days at 4 °C. CONCLUSIONS: When compared with ambient or refrigerated storage conditions, omeprazole was stable for a longer duration than lansoprazole. Pharmacists may use these results to guide compounding and storage of proton-pump inhibitor suspensions.

Original languageEnglish (US)
Pages (from-to)600-605
Number of pages6
JournalAnnals of Pharmacotherapy
Volume34
Issue number5
DOIs
StatePublished - Jan 1 2000

Fingerprint

Amber
Lansoprazole
Omeprazole
Syringes
Plastics
Suspensions
High Pressure Liquid Chromatography
Sodium Bicarbonate
Proton Pump Inhibitors
Pharmacists
Capsules
Temperature
Pharmaceutical Preparations

Keywords

  • Lansoprazole
  • Omeprazole
  • Stability

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Stability of suspension formulations of lansoprazole and omeprazole stored in amber-colored plastic oral syringes. / DiGiacinto, Jennifer L.; Olsen, Keith Melvin; Bergman, Kimberly L.; Hoie, Eric B.

In: Annals of Pharmacotherapy, Vol. 34, No. 5, 01.01.2000, p. 600-605.

Research output: Contribution to journalArticle

DiGiacinto, Jennifer L. ; Olsen, Keith Melvin ; Bergman, Kimberly L. ; Hoie, Eric B. / Stability of suspension formulations of lansoprazole and omeprazole stored in amber-colored plastic oral syringes. In: Annals of Pharmacotherapy. 2000 ; Vol. 34, No. 5. pp. 600-605.
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N2 - OBJECTIVE: To determine the stability of lansoprazole and omeprazole suspensions at ambient and refrigerated temperatures using HPLC. DESIGN: The contents of lansoprazole and omeprazole capsules were suspended in separate flasks containing sodium bicarbonate 8.4% to concentrations of 3 and 2 mg/mL, respectively. The contents of each flask were drawn into six amber-colored oral syringes, with one-half of the syringes stored at 22 °C (ambient) and the other half at 4 °C. Lansoprazole and omeprazole concentrations were determined by a stability-indicating HPLC assay at baseline and at 4, 8, 12, and 24 hours, and on days 4, 7, 14, 21, 30, 45, and 60 after mixing. Both omeprazole and lansoprazole were considered stable if they retained ≥90% of the baseline drug concentration. RESULTS: Omeprazole was stable for up to 14 days at 22 °C and 45 days at 4 °C. Lansoprazole was stable for eight hours at 22 °C and for 14 days at 4 °C. CONCLUSIONS: When compared with ambient or refrigerated storage conditions, omeprazole was stable for a longer duration than lansoprazole. Pharmacists may use these results to guide compounding and storage of proton-pump inhibitor suspensions.

AB - OBJECTIVE: To determine the stability of lansoprazole and omeprazole suspensions at ambient and refrigerated temperatures using HPLC. DESIGN: The contents of lansoprazole and omeprazole capsules were suspended in separate flasks containing sodium bicarbonate 8.4% to concentrations of 3 and 2 mg/mL, respectively. The contents of each flask were drawn into six amber-colored oral syringes, with one-half of the syringes stored at 22 °C (ambient) and the other half at 4 °C. Lansoprazole and omeprazole concentrations were determined by a stability-indicating HPLC assay at baseline and at 4, 8, 12, and 24 hours, and on days 4, 7, 14, 21, 30, 45, and 60 after mixing. Both omeprazole and lansoprazole were considered stable if they retained ≥90% of the baseline drug concentration. RESULTS: Omeprazole was stable for up to 14 days at 22 °C and 45 days at 4 °C. Lansoprazole was stable for eight hours at 22 °C and for 14 days at 4 °C. CONCLUSIONS: When compared with ambient or refrigerated storage conditions, omeprazole was stable for a longer duration than lansoprazole. Pharmacists may use these results to guide compounding and storage of proton-pump inhibitor suspensions.

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