Spontaneous closure of the human fetal ductus arteriosus - A cause of fetal congestive heart failure

G. Hofstadler, G. Tulzer, R. Altmann, K. Schmitt, D. Danford, J. C. Huhta

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

OBJECTIVE: Closure of the fetal ductus arteriosus, which is usually due to nonsteroidal antiinflammatory agents, may be detrimental. Therefore prenatal and postnatal clinical and echocardiographic findings in four human fetuses with spontaneous ductus arteriosus occlusion are reported. STUDY DESIGN: Echocardiographic and clinical data were retrospectively analyzed. RESULTS: Spontaneous closure of the ductus arteriosus was discovered in four fetuses (gestational age 34 to 38 weeks). No mother had received nonsteroidal antiinflammatory agents. Enlargement of the right heart and pulmonary arteries and tricuspid and pulmonary regurgitation were present in all cases. Two fetuses had right ventricular hypertension. Postnatally their right ventricular function recovered promptly. The others had severe right heart failure with abnormal umbilical venous pulsations. After immediate delivery none had signs of persistent pulmonary hypertension. However, they have echocardiographic evidence of right ventricular dysfunction 2 to 6 months after delivery. CONCLUSIONS: Occlusion of the fetal ductus arteriosus may also occur in the absence of treatment with nonsteroidal antiinflammatory agents. Immediate delivery resulted in good clinical outcome, although right ventricular dysfunction may persist.

Original languageEnglish (US)
Pages (from-to)879-883
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume174
Issue number3
DOIs
StatePublished - Jan 1 1996

Fingerprint

Ductus Arteriosus
Fetal Heart
Non-Steroidal Anti-Inflammatory Agents
Heart Failure
Right Ventricular Dysfunction
Fetus
Pulmonary Valve Insufficiency
Umbilicus
Right Ventricular Function
Tricuspid Valve Insufficiency
Cardiomegaly
Pulmonary Hypertension
Pulmonary Artery
Gestational Age
Hypertension

Keywords

  • Doppler echocardiography
  • Fetal ductus arteriosus
  • congestive heart failure

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Spontaneous closure of the human fetal ductus arteriosus - A cause of fetal congestive heart failure. / Hofstadler, G.; Tulzer, G.; Altmann, R.; Schmitt, K.; Danford, D.; Huhta, J. C.

In: American Journal of Obstetrics and Gynecology, Vol. 174, No. 3, 01.01.1996, p. 879-883.

Research output: Contribution to journalArticle

Hofstadler, G. ; Tulzer, G. ; Altmann, R. ; Schmitt, K. ; Danford, D. ; Huhta, J. C. / Spontaneous closure of the human fetal ductus arteriosus - A cause of fetal congestive heart failure. In: American Journal of Obstetrics and Gynecology. 1996 ; Vol. 174, No. 3. pp. 879-883.
@article{2610eb0fa7fe44b09abd488b85914427,
title = "Spontaneous closure of the human fetal ductus arteriosus - A cause of fetal congestive heart failure",
abstract = "OBJECTIVE: Closure of the fetal ductus arteriosus, which is usually due to nonsteroidal antiinflammatory agents, may be detrimental. Therefore prenatal and postnatal clinical and echocardiographic findings in four human fetuses with spontaneous ductus arteriosus occlusion are reported. STUDY DESIGN: Echocardiographic and clinical data were retrospectively analyzed. RESULTS: Spontaneous closure of the ductus arteriosus was discovered in four fetuses (gestational age 34 to 38 weeks). No mother had received nonsteroidal antiinflammatory agents. Enlargement of the right heart and pulmonary arteries and tricuspid and pulmonary regurgitation were present in all cases. Two fetuses had right ventricular hypertension. Postnatally their right ventricular function recovered promptly. The others had severe right heart failure with abnormal umbilical venous pulsations. After immediate delivery none had signs of persistent pulmonary hypertension. However, they have echocardiographic evidence of right ventricular dysfunction 2 to 6 months after delivery. CONCLUSIONS: Occlusion of the fetal ductus arteriosus may also occur in the absence of treatment with nonsteroidal antiinflammatory agents. Immediate delivery resulted in good clinical outcome, although right ventricular dysfunction may persist.",
keywords = "Doppler echocardiography, Fetal ductus arteriosus, congestive heart failure",
author = "G. Hofstadler and G. Tulzer and R. Altmann and K. Schmitt and D. Danford and Huhta, {J. C.}",
year = "1996",
month = "1",
day = "1",
doi = "10.1016/S0002-9378(96)70317-4",
language = "English (US)",
volume = "174",
pages = "879--883",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Spontaneous closure of the human fetal ductus arteriosus - A cause of fetal congestive heart failure

AU - Hofstadler, G.

AU - Tulzer, G.

AU - Altmann, R.

AU - Schmitt, K.

AU - Danford, D.

AU - Huhta, J. C.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - OBJECTIVE: Closure of the fetal ductus arteriosus, which is usually due to nonsteroidal antiinflammatory agents, may be detrimental. Therefore prenatal and postnatal clinical and echocardiographic findings in four human fetuses with spontaneous ductus arteriosus occlusion are reported. STUDY DESIGN: Echocardiographic and clinical data were retrospectively analyzed. RESULTS: Spontaneous closure of the ductus arteriosus was discovered in four fetuses (gestational age 34 to 38 weeks). No mother had received nonsteroidal antiinflammatory agents. Enlargement of the right heart and pulmonary arteries and tricuspid and pulmonary regurgitation were present in all cases. Two fetuses had right ventricular hypertension. Postnatally their right ventricular function recovered promptly. The others had severe right heart failure with abnormal umbilical venous pulsations. After immediate delivery none had signs of persistent pulmonary hypertension. However, they have echocardiographic evidence of right ventricular dysfunction 2 to 6 months after delivery. CONCLUSIONS: Occlusion of the fetal ductus arteriosus may also occur in the absence of treatment with nonsteroidal antiinflammatory agents. Immediate delivery resulted in good clinical outcome, although right ventricular dysfunction may persist.

AB - OBJECTIVE: Closure of the fetal ductus arteriosus, which is usually due to nonsteroidal antiinflammatory agents, may be detrimental. Therefore prenatal and postnatal clinical and echocardiographic findings in four human fetuses with spontaneous ductus arteriosus occlusion are reported. STUDY DESIGN: Echocardiographic and clinical data were retrospectively analyzed. RESULTS: Spontaneous closure of the ductus arteriosus was discovered in four fetuses (gestational age 34 to 38 weeks). No mother had received nonsteroidal antiinflammatory agents. Enlargement of the right heart and pulmonary arteries and tricuspid and pulmonary regurgitation were present in all cases. Two fetuses had right ventricular hypertension. Postnatally their right ventricular function recovered promptly. The others had severe right heart failure with abnormal umbilical venous pulsations. After immediate delivery none had signs of persistent pulmonary hypertension. However, they have echocardiographic evidence of right ventricular dysfunction 2 to 6 months after delivery. CONCLUSIONS: Occlusion of the fetal ductus arteriosus may also occur in the absence of treatment with nonsteroidal antiinflammatory agents. Immediate delivery resulted in good clinical outcome, although right ventricular dysfunction may persist.

KW - Doppler echocardiography

KW - Fetal ductus arteriosus

KW - congestive heart failure

UR - http://www.scopus.com/inward/record.url?scp=0029878966&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029878966&partnerID=8YFLogxK

U2 - 10.1016/S0002-9378(96)70317-4

DO - 10.1016/S0002-9378(96)70317-4

M3 - Article

C2 - 8633660

AN - SCOPUS:0029878966

VL - 174

SP - 879

EP - 883

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 3

ER -