Spontaneous and induced sister chromatid exchange frequencies and cell cycle progression in lymphocytes of patients with carcinoma of the uterine cervix

Siddharth G. Adhvaryu, Rohini C. Vyas, Bhavana J. Dave, Amit H. Trivedi, Bharati N. Parikh

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Thirteen healthy females and thirteen untreated patients with carcinoma of the uterine cervix were studied for spontaneous and mitomycin C (MMC)-induced rates of sister chromatid exchange (SCE) and cell cycle progression. The mean values of spontaneous as well as MMC-induced SCE rates showed no statistically significant difference between groups. For studying cell cycle progression, cells in the M1, M2, and M3 stages were scored from the same samples. The percent values of cells in these stages, identified by the nature of differential sister chromatid staining, were found to be almost identical in normal as well as MMC-treated cultures in controls and patients. It was concluded that the presence of carcinoma of the uterine cervix in human females has no bearing either on spontaneous and MMC-induced SCE rates or on cell cycle progression in PHA-stimulated cultures of peripheral blood lymphocytes.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalCancer genetics and cytogenetics
Volume14
Issue number1-2
DOIs
StatePublished - Jan 1 1985

Fingerprint

Sister Chromatid Exchange
Mitomycin
Cervix Uteri
Cell Cycle
Lymphocytes
Carcinoma
Chromatids
Siblings
Staining and Labeling

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Spontaneous and induced sister chromatid exchange frequencies and cell cycle progression in lymphocytes of patients with carcinoma of the uterine cervix. / Adhvaryu, Siddharth G.; Vyas, Rohini C.; Dave, Bhavana J.; Trivedi, Amit H.; Parikh, Bharati N.

In: Cancer genetics and cytogenetics, Vol. 14, No. 1-2, 01.01.1985, p. 67-72.

Research output: Contribution to journalArticle

@article{27cf87bd920e40dab9534051d77b3893,
title = "Spontaneous and induced sister chromatid exchange frequencies and cell cycle progression in lymphocytes of patients with carcinoma of the uterine cervix",
abstract = "Thirteen healthy females and thirteen untreated patients with carcinoma of the uterine cervix were studied for spontaneous and mitomycin C (MMC)-induced rates of sister chromatid exchange (SCE) and cell cycle progression. The mean values of spontaneous as well as MMC-induced SCE rates showed no statistically significant difference between groups. For studying cell cycle progression, cells in the M1, M2, and M3 stages were scored from the same samples. The percent values of cells in these stages, identified by the nature of differential sister chromatid staining, were found to be almost identical in normal as well as MMC-treated cultures in controls and patients. It was concluded that the presence of carcinoma of the uterine cervix in human females has no bearing either on spontaneous and MMC-induced SCE rates or on cell cycle progression in PHA-stimulated cultures of peripheral blood lymphocytes.",
author = "Adhvaryu, {Siddharth G.} and Vyas, {Rohini C.} and Dave, {Bhavana J.} and Trivedi, {Amit H.} and Parikh, {Bharati N.}",
year = "1985",
month = "1",
day = "1",
doi = "10.1016/0165-4608(85)90216-X",
language = "English (US)",
volume = "14",
pages = "67--72",
journal = "Cancer Genetics and Cytogenetics",
issn = "0165-4608",
publisher = "Elsevier Inc.",
number = "1-2",

}

TY - JOUR

T1 - Spontaneous and induced sister chromatid exchange frequencies and cell cycle progression in lymphocytes of patients with carcinoma of the uterine cervix

AU - Adhvaryu, Siddharth G.

AU - Vyas, Rohini C.

AU - Dave, Bhavana J.

AU - Trivedi, Amit H.

AU - Parikh, Bharati N.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - Thirteen healthy females and thirteen untreated patients with carcinoma of the uterine cervix were studied for spontaneous and mitomycin C (MMC)-induced rates of sister chromatid exchange (SCE) and cell cycle progression. The mean values of spontaneous as well as MMC-induced SCE rates showed no statistically significant difference between groups. For studying cell cycle progression, cells in the M1, M2, and M3 stages were scored from the same samples. The percent values of cells in these stages, identified by the nature of differential sister chromatid staining, were found to be almost identical in normal as well as MMC-treated cultures in controls and patients. It was concluded that the presence of carcinoma of the uterine cervix in human females has no bearing either on spontaneous and MMC-induced SCE rates or on cell cycle progression in PHA-stimulated cultures of peripheral blood lymphocytes.

AB - Thirteen healthy females and thirteen untreated patients with carcinoma of the uterine cervix were studied for spontaneous and mitomycin C (MMC)-induced rates of sister chromatid exchange (SCE) and cell cycle progression. The mean values of spontaneous as well as MMC-induced SCE rates showed no statistically significant difference between groups. For studying cell cycle progression, cells in the M1, M2, and M3 stages were scored from the same samples. The percent values of cells in these stages, identified by the nature of differential sister chromatid staining, were found to be almost identical in normal as well as MMC-treated cultures in controls and patients. It was concluded that the presence of carcinoma of the uterine cervix in human females has no bearing either on spontaneous and MMC-induced SCE rates or on cell cycle progression in PHA-stimulated cultures of peripheral blood lymphocytes.

UR - http://www.scopus.com/inward/record.url?scp=0021919937&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021919937&partnerID=8YFLogxK

U2 - 10.1016/0165-4608(85)90216-X

DO - 10.1016/0165-4608(85)90216-X

M3 - Article

C2 - 3917367

AN - SCOPUS:0021919937

VL - 14

SP - 67

EP - 72

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

SN - 0165-4608

IS - 1-2

ER -