Speed of tooth movement is related to stress and IL-1 gene polymorphisms

Laura R. Iwasaki, Colin S. Gibson, Larry D. Crouch, David B. Marx, Janardan P. Pandey, Jeffrey C. Nickel

Research output: Contribution to journalArticle

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Abstract

Introduction: The variables affecting speed of tooth movement are unquantified. In particular, the effects of stress and human biological variations are unknown. Therefore, our objectives in this study were to determine relationships between (1) stress and velocity of tooth translation (vt), and (2) interleukin-1 (IL-1) gene cluster polymorphisms, IL-1β and IL-1 receptor antagonist (IL-1RA) in gingival crevicular fluid (GCF), and vt. Methods: Ten subjects had their maxillary first premolars extracted and cheek wipe samples genotyped. In each subject, a maxillary canine received 26 kPa and the other received 13 or 52 kPa of stress. GCF samples and tooth movements were measured at 9 or 10 visits over 84 days. Results: Mean vt for canines retracted by 13, 26, and 52 kPa were 0.054, 0.072, and 0.064 mm per day, respectively. Faster vt was shown from 26 kPa than 13 kPa (P = .015) and 52 kPa (P = .030), with higher IL-1β/IL-1RA in GCF at experimental relative to control sites, and in subjects with homozygosity for allele 1 (A1,A1) compared with at least 1 copy of A2 (A2+) at IL-1RN(VNTR86 bp) (P = .032), and with A2+ compared with A1,A1 at IL-1B(+3954) (P = .051). Conclusions: Stress, IL-1β/IL-1RA in GCF, and IL-1 gene cluster polymorphisms are related to vt.

Original languageEnglish (US)
Pages (from-to)698.e1-698.e9
JournalAmerican Journal of Orthodontics and Dentofacial Orthopedics
Volume130
Issue number6
DOIs
StatePublished - Dec 2006

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Tooth Movement Techniques
Gingival Crevicular Fluid
Interleukin-1
Interleukin-1 Receptors
varespladib methyl
Genes
Multigene Family
Canidae
Cheek
Bicuspid
Tooth
Alleles

ASJC Scopus subject areas

  • Orthodontics

Cite this

Speed of tooth movement is related to stress and IL-1 gene polymorphisms. / Iwasaki, Laura R.; Gibson, Colin S.; Crouch, Larry D.; Marx, David B.; Pandey, Janardan P.; Nickel, Jeffrey C.

In: American Journal of Orthodontics and Dentofacial Orthopedics, Vol. 130, No. 6, 12.2006, p. 698.e1-698.e9.

Research output: Contribution to journalArticle

Iwasaki, Laura R. ; Gibson, Colin S. ; Crouch, Larry D. ; Marx, David B. ; Pandey, Janardan P. ; Nickel, Jeffrey C. / Speed of tooth movement is related to stress and IL-1 gene polymorphisms. In: American Journal of Orthodontics and Dentofacial Orthopedics. 2006 ; Vol. 130, No. 6. pp. 698.e1-698.e9.
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AU - Nickel, Jeffrey C.

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N2 - Introduction: The variables affecting speed of tooth movement are unquantified. In particular, the effects of stress and human biological variations are unknown. Therefore, our objectives in this study were to determine relationships between (1) stress and velocity of tooth translation (vt), and (2) interleukin-1 (IL-1) gene cluster polymorphisms, IL-1β and IL-1 receptor antagonist (IL-1RA) in gingival crevicular fluid (GCF), and vt. Methods: Ten subjects had their maxillary first premolars extracted and cheek wipe samples genotyped. In each subject, a maxillary canine received 26 kPa and the other received 13 or 52 kPa of stress. GCF samples and tooth movements were measured at 9 or 10 visits over 84 days. Results: Mean vt for canines retracted by 13, 26, and 52 kPa were 0.054, 0.072, and 0.064 mm per day, respectively. Faster vt was shown from 26 kPa than 13 kPa (P = .015) and 52 kPa (P = .030), with higher IL-1β/IL-1RA in GCF at experimental relative to control sites, and in subjects with homozygosity for allele 1 (A1,A1) compared with at least 1 copy of A2 (A2+) at IL-1RN(VNTR86 bp) (P = .032), and with A2+ compared with A1,A1 at IL-1B(+3954) (P = .051). Conclusions: Stress, IL-1β/IL-1RA in GCF, and IL-1 gene cluster polymorphisms are related to vt.

AB - Introduction: The variables affecting speed of tooth movement are unquantified. In particular, the effects of stress and human biological variations are unknown. Therefore, our objectives in this study were to determine relationships between (1) stress and velocity of tooth translation (vt), and (2) interleukin-1 (IL-1) gene cluster polymorphisms, IL-1β and IL-1 receptor antagonist (IL-1RA) in gingival crevicular fluid (GCF), and vt. Methods: Ten subjects had their maxillary first premolars extracted and cheek wipe samples genotyped. In each subject, a maxillary canine received 26 kPa and the other received 13 or 52 kPa of stress. GCF samples and tooth movements were measured at 9 or 10 visits over 84 days. Results: Mean vt for canines retracted by 13, 26, and 52 kPa were 0.054, 0.072, and 0.064 mm per day, respectively. Faster vt was shown from 26 kPa than 13 kPa (P = .015) and 52 kPa (P = .030), with higher IL-1β/IL-1RA in GCF at experimental relative to control sites, and in subjects with homozygosity for allele 1 (A1,A1) compared with at least 1 copy of A2 (A2+) at IL-1RN(VNTR86 bp) (P = .032), and with A2+ compared with A1,A1 at IL-1B(+3954) (P = .051). Conclusions: Stress, IL-1β/IL-1RA in GCF, and IL-1 gene cluster polymorphisms are related to vt.

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