Spectral-domain optical coherence tomography epithelial and flap thickness mapping in femtosecond laser-assisted in situ keratomileusis

Karolinne Maia Rocha, Ronald R. Krueger

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Abstract

Purpose To evaluate the change of epithelial and flap thickness after femtosecond laser-assisted in situ keratomileusis (LASIK) using spectral-domain optical coherence tomography (SD OCT) in correlation with the spherical equivalent refraction treated and clinical outcomes. Design Prospective, randomized, contralateral-eye study. Methods Forty myopic eyes underwent LASIK using an excimer laser with refraction ranging from -1.00 to -7.25 diopters (mean -3.25 ± 1.9). Flap creation was randomized between eyes, using the IntraLASE FS60 laser (IL) in 1 eye and WaveLight FS200 laser (FS) in the contralateral eye. SD OCT was used to evaluate the epithelial and flap thickness profiles and corneal power preoperatively and at 1 week and 1, 3, and 9 months postoperatively. Manifest and wavefront refractions were performed at each postoperative visit. Results Statistically significant epithelial thickening was observed in both IL and FS groups as early as 1 month postoperatively (P =.033 and P =.042), but this stabilized between 3 (P =.042 and P =.035) and 9 months (P =.043 and P =.041). Femtosecond-LASIK flaps were thicker in the IL group in comparison to the FS group at 3 and 9 months postoperatively (P =.003 and P =.005, respectively). There was a statistically significant correlation between the magnitude of preoperative myopic refraction and the central epithelial thickness at 1, 3, and 9 months (Pearson correlation coefficients 0.485, 0.587 and 0.576) (P =.0021, P =.0010, and P =.0011), respectively. SD OCT corneal power maps showed steepening at 3 and 9 months along with mild myopic shift. Conclusion Progressive epithelial and flap thickening with increased corneal power were observed after femtosecond laser-assisted in situ keratomileusis for myopia with consequent stabilization between 3 to 9 months postoperatively. The magnitude of epithelial and flap thickness remodeling correlated to the preoperative myopic refractive error.

Original languageEnglish (US)
Pages (from-to)293-301.e1
JournalAmerican journal of ophthalmology
Volume158
Issue number2
DOIs
StatePublished - Aug 2014

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Laser In Situ Keratomileusis
Optical Coherence Tomography
Lasers
Excimer Lasers
Refractive Errors
Myopia

ASJC Scopus subject areas

  • Ophthalmology

Cite this

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title = "Spectral-domain optical coherence tomography epithelial and flap thickness mapping in femtosecond laser-assisted in situ keratomileusis",
abstract = "Purpose To evaluate the change of epithelial and flap thickness after femtosecond laser-assisted in situ keratomileusis (LASIK) using spectral-domain optical coherence tomography (SD OCT) in correlation with the spherical equivalent refraction treated and clinical outcomes. Design Prospective, randomized, contralateral-eye study. Methods Forty myopic eyes underwent LASIK using an excimer laser with refraction ranging from -1.00 to -7.25 diopters (mean -3.25 ± 1.9). Flap creation was randomized between eyes, using the IntraLASE FS60 laser (IL) in 1 eye and WaveLight FS200 laser (FS) in the contralateral eye. SD OCT was used to evaluate the epithelial and flap thickness profiles and corneal power preoperatively and at 1 week and 1, 3, and 9 months postoperatively. Manifest and wavefront refractions were performed at each postoperative visit. Results Statistically significant epithelial thickening was observed in both IL and FS groups as early as 1 month postoperatively (P =.033 and P =.042), but this stabilized between 3 (P =.042 and P =.035) and 9 months (P =.043 and P =.041). Femtosecond-LASIK flaps were thicker in the IL group in comparison to the FS group at 3 and 9 months postoperatively (P =.003 and P =.005, respectively). There was a statistically significant correlation between the magnitude of preoperative myopic refraction and the central epithelial thickness at 1, 3, and 9 months (Pearson correlation coefficients 0.485, 0.587 and 0.576) (P =.0021, P =.0010, and P =.0011), respectively. SD OCT corneal power maps showed steepening at 3 and 9 months along with mild myopic shift. Conclusion Progressive epithelial and flap thickening with increased corneal power were observed after femtosecond laser-assisted in situ keratomileusis for myopia with consequent stabilization between 3 to 9 months postoperatively. The magnitude of epithelial and flap thickness remodeling correlated to the preoperative myopic refractive error.",
author = "{Maia Rocha}, Karolinne and Krueger, {Ronald R.}",
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N2 - Purpose To evaluate the change of epithelial and flap thickness after femtosecond laser-assisted in situ keratomileusis (LASIK) using spectral-domain optical coherence tomography (SD OCT) in correlation with the spherical equivalent refraction treated and clinical outcomes. Design Prospective, randomized, contralateral-eye study. Methods Forty myopic eyes underwent LASIK using an excimer laser with refraction ranging from -1.00 to -7.25 diopters (mean -3.25 ± 1.9). Flap creation was randomized between eyes, using the IntraLASE FS60 laser (IL) in 1 eye and WaveLight FS200 laser (FS) in the contralateral eye. SD OCT was used to evaluate the epithelial and flap thickness profiles and corneal power preoperatively and at 1 week and 1, 3, and 9 months postoperatively. Manifest and wavefront refractions were performed at each postoperative visit. Results Statistically significant epithelial thickening was observed in both IL and FS groups as early as 1 month postoperatively (P =.033 and P =.042), but this stabilized between 3 (P =.042 and P =.035) and 9 months (P =.043 and P =.041). Femtosecond-LASIK flaps were thicker in the IL group in comparison to the FS group at 3 and 9 months postoperatively (P =.003 and P =.005, respectively). There was a statistically significant correlation between the magnitude of preoperative myopic refraction and the central epithelial thickness at 1, 3, and 9 months (Pearson correlation coefficients 0.485, 0.587 and 0.576) (P =.0021, P =.0010, and P =.0011), respectively. SD OCT corneal power maps showed steepening at 3 and 9 months along with mild myopic shift. Conclusion Progressive epithelial and flap thickening with increased corneal power were observed after femtosecond laser-assisted in situ keratomileusis for myopia with consequent stabilization between 3 to 9 months postoperatively. The magnitude of epithelial and flap thickness remodeling correlated to the preoperative myopic refractive error.

AB - Purpose To evaluate the change of epithelial and flap thickness after femtosecond laser-assisted in situ keratomileusis (LASIK) using spectral-domain optical coherence tomography (SD OCT) in correlation with the spherical equivalent refraction treated and clinical outcomes. Design Prospective, randomized, contralateral-eye study. Methods Forty myopic eyes underwent LASIK using an excimer laser with refraction ranging from -1.00 to -7.25 diopters (mean -3.25 ± 1.9). Flap creation was randomized between eyes, using the IntraLASE FS60 laser (IL) in 1 eye and WaveLight FS200 laser (FS) in the contralateral eye. SD OCT was used to evaluate the epithelial and flap thickness profiles and corneal power preoperatively and at 1 week and 1, 3, and 9 months postoperatively. Manifest and wavefront refractions were performed at each postoperative visit. Results Statistically significant epithelial thickening was observed in both IL and FS groups as early as 1 month postoperatively (P =.033 and P =.042), but this stabilized between 3 (P =.042 and P =.035) and 9 months (P =.043 and P =.041). Femtosecond-LASIK flaps were thicker in the IL group in comparison to the FS group at 3 and 9 months postoperatively (P =.003 and P =.005, respectively). There was a statistically significant correlation between the magnitude of preoperative myopic refraction and the central epithelial thickness at 1, 3, and 9 months (Pearson correlation coefficients 0.485, 0.587 and 0.576) (P =.0021, P =.0010, and P =.0011), respectively. SD OCT corneal power maps showed steepening at 3 and 9 months along with mild myopic shift. Conclusion Progressive epithelial and flap thickening with increased corneal power were observed after femtosecond laser-assisted in situ keratomileusis for myopia with consequent stabilization between 3 to 9 months postoperatively. The magnitude of epithelial and flap thickness remodeling correlated to the preoperative myopic refractive error.

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