Spectral assignments for the aldose reductase inhibitor 4(S)-2,3-dihydro-6-fluoro-2(R)-methylspiro[chroman-4,4′-imidazoline] -2′,5′-dione and its synthetic intermediates

Mingan Wang, Manoj K. Mishra, Wenjun Zhu, Peter F Kador

Research output: Contribution to journalArticle

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The 1H and 13C NMR chemical shifts of the aldose reductase inhibitor 4(S)-2,3-dihydro-6-fluoro-2(R)-methylspiro[chroman-4, 4′-imidazoline]-2′,5′-dione, methylsorbinil, and its seven synthetic intermediates, have been completely assigned on the basis of DEPT, COSY, g-HSQC and g-HMBC. All C-F coupling constants from one-bond to four-bond in the 13C NMR spectra and H-F and H-H coupling constants from three-bond to four-bond in 1H spectra were obtained.

Original languageEnglish (US)
Pages (from-to)1008-1011
Number of pages4
JournalMagnetic Resonance in Chemistry
Issue number12
Publication statusPublished - Dec 1 2005



  • 2D NMR
  • Aldose reductase inhibitor
  • C NMR
  • C-F and H-F coupling constants
  • DEPT
  • H NMR
  • Methylsorbinil

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)

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