Spectral assignments for the aldose reductase inhibitor 4(S)-2,3-dihydro-6-fluoro-2(R)-methylspiro[chroman-4,4′-imidazoline] -2′,5′-dione and its synthetic intermediates

Mingan Wang, Manoj K. Mishra, Wenjun Zhu, Peter F Kador

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The 1H and 13C NMR chemical shifts of the aldose reductase inhibitor 4(S)-2,3-dihydro-6-fluoro-2(R)-methylspiro[chroman-4, 4′-imidazoline]-2′,5′-dione, methylsorbinil, and its seven synthetic intermediates, have been completely assigned on the basis of DEPT, COSY, g-HSQC and g-HMBC. All C-F coupling constants from one-bond to four-bond in the 13C NMR spectra and H-F and H-H coupling constants from three-bond to four-bond in 1H spectra were obtained.

Original languageEnglish (US)
Pages (from-to)1008-1011
Number of pages4
JournalMagnetic Resonance in Chemistry
Volume43
Issue number12
DOIs
StatePublished - Dec 1 2005

Fingerprint

Chromans
Aldehyde Reductase
Dione
inhibitors
Nuclear magnetic resonance
nuclear magnetic resonance
Chemical shift
chemical equilibrium
2-imidazoline
Oxidoreductases

Keywords

  • 2D NMR
  • Aldose reductase inhibitor
  • C NMR
  • C-F and H-F coupling constants
  • DEPT
  • H NMR
  • Methylsorbinil

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)

Cite this

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title = "Spectral assignments for the aldose reductase inhibitor 4(S)-2,3-dihydro-6-fluoro-2(R)-methylspiro[chroman-4,4′-imidazoline] -2′,5′-dione and its synthetic intermediates",
abstract = "The 1H and 13C NMR chemical shifts of the aldose reductase inhibitor 4(S)-2,3-dihydro-6-fluoro-2(R)-methylspiro[chroman-4, 4′-imidazoline]-2′,5′-dione, methylsorbinil, and its seven synthetic intermediates, have been completely assigned on the basis of DEPT, COSY, g-HSQC and g-HMBC. All C-F coupling constants from one-bond to four-bond in the 13C NMR spectra and H-F and H-H coupling constants from three-bond to four-bond in 1H spectra were obtained.",
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T1 - Spectral assignments for the aldose reductase inhibitor 4(S)-2,3-dihydro-6-fluoro-2(R)-methylspiro[chroman-4,4′-imidazoline] -2′,5′-dione and its synthetic intermediates

AU - Wang, Mingan

AU - Mishra, Manoj K.

AU - Zhu, Wenjun

AU - Kador, Peter F

PY - 2005/12/1

Y1 - 2005/12/1

N2 - The 1H and 13C NMR chemical shifts of the aldose reductase inhibitor 4(S)-2,3-dihydro-6-fluoro-2(R)-methylspiro[chroman-4, 4′-imidazoline]-2′,5′-dione, methylsorbinil, and its seven synthetic intermediates, have been completely assigned on the basis of DEPT, COSY, g-HSQC and g-HMBC. All C-F coupling constants from one-bond to four-bond in the 13C NMR spectra and H-F and H-H coupling constants from three-bond to four-bond in 1H spectra were obtained.

AB - The 1H and 13C NMR chemical shifts of the aldose reductase inhibitor 4(S)-2,3-dihydro-6-fluoro-2(R)-methylspiro[chroman-4, 4′-imidazoline]-2′,5′-dione, methylsorbinil, and its seven synthetic intermediates, have been completely assigned on the basis of DEPT, COSY, g-HSQC and g-HMBC. All C-F coupling constants from one-bond to four-bond in the 13C NMR spectra and H-F and H-H coupling constants from three-bond to four-bond in 1H spectra were obtained.

KW - 2D NMR

KW - Aldose reductase inhibitor

KW - C NMR

KW - C-F and H-F coupling constants

KW - DEPT

KW - H NMR

KW - Methylsorbinil

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