Specific Uptake of the Auger Electron-emitting Thymidine Analogue 5-[123I/125I]Iodo-2'-deoxyuridine in Rat Brain Tumors: Diagnostic and Therapeutic Implications in Humans

Amin I. Kassis, Annick D. Van den Abbeele, Janina Baranowska-Kortylewicz, William C. DeSisto, Rebecca A. Aaronson, S. James Adelstein, Patrick Y.C. Wen, Lois A. Lampson, Peter Mc L. Black

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Glial neoplasms of the human central nervous system are malignancies that have defied treatment. Part of the problem lies in the limitations of current diagnostic techniques which are unable to identify small collections of neoplastic glia within normal parenchyma and in the difficulty of sterilizing these tumors because of limited selectivity of the cytotoxic agents available. The thymidine analogue 5-iodo-2'-deoxyuridine (IdUrd) radiolabeled with, 23I and 125I was injected directly into an intracerebral rat 9L gliosarcoma and found to be a sensitive and specific agent for the detection of this neoplasm in rats. External gamma camera imaging (,23I) visualized tumors as small as 0.5 mm in diameter. Autoradiography (125I) indicated that IdUrd was incorporated into the DNA of neoplastic glia only. Since 123I emits γ-photons suitable for scintigraphy, [123I]IdUrd holds promise for the diagnosis of brain tumors in humans as well. Furthermore, since 123I and, 25I are Auger electron emitters that have demonstrated antineoplastic effects, direct administration of [123I]IdUrd or [125I]IdUrd into tumors may also have potential for the treatment of central nervous system malignancies.

Original languageEnglish (US)
Pages (from-to)5199-5203
Number of pages5
JournalCancer Research
Volume50
Issue number16
StatePublished - Aug 15 1990

Fingerprint

Deoxyuridine
Brain Neoplasms
Thymidine
Electrons
Neuroglia
Neoplasms
Radionuclide Imaging
Therapeutics
Gliosarcoma
Idoxuridine
Central Nervous System Neoplasms
Cytotoxins
Autoradiography
Photons
Antineoplastic Agents
Central Nervous System
DNA

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Specific Uptake of the Auger Electron-emitting Thymidine Analogue 5-[123I/125I]Iodo-2'-deoxyuridine in Rat Brain Tumors : Diagnostic and Therapeutic Implications in Humans. / Kassis, Amin I.; Van den Abbeele, Annick D.; Baranowska-Kortylewicz, Janina; DeSisto, William C.; Aaronson, Rebecca A.; Adelstein, S. James; Wen, Patrick Y.C.; Lampson, Lois A.; Black, Peter Mc L.

In: Cancer Research, Vol. 50, No. 16, 15.08.1990, p. 5199-5203.

Research output: Contribution to journalArticle

Kassis, AI, Van den Abbeele, AD, Baranowska-Kortylewicz, J, DeSisto, WC, Aaronson, RA, Adelstein, SJ, Wen, PYC, Lampson, LA & Black, PML 1990, 'Specific Uptake of the Auger Electron-emitting Thymidine Analogue 5-[123I/125I]Iodo-2'-deoxyuridine in Rat Brain Tumors: Diagnostic and Therapeutic Implications in Humans', Cancer Research, vol. 50, no. 16, pp. 5199-5203.
Kassis, Amin I. ; Van den Abbeele, Annick D. ; Baranowska-Kortylewicz, Janina ; DeSisto, William C. ; Aaronson, Rebecca A. ; Adelstein, S. James ; Wen, Patrick Y.C. ; Lampson, Lois A. ; Black, Peter Mc L. / Specific Uptake of the Auger Electron-emitting Thymidine Analogue 5-[123I/125I]Iodo-2'-deoxyuridine in Rat Brain Tumors : Diagnostic and Therapeutic Implications in Humans. In: Cancer Research. 1990 ; Vol. 50, No. 16. pp. 5199-5203.
@article{e4357d03bbda46aea272c52ed2ac1c00,
title = "Specific Uptake of the Auger Electron-emitting Thymidine Analogue 5-[123I/125I]Iodo-2'-deoxyuridine in Rat Brain Tumors: Diagnostic and Therapeutic Implications in Humans",
abstract = "Glial neoplasms of the human central nervous system are malignancies that have defied treatment. Part of the problem lies in the limitations of current diagnostic techniques which are unable to identify small collections of neoplastic glia within normal parenchyma and in the difficulty of sterilizing these tumors because of limited selectivity of the cytotoxic agents available. The thymidine analogue 5-iodo-2'-deoxyuridine (IdUrd) radiolabeled with, 23I and 125I was injected directly into an intracerebral rat 9L gliosarcoma and found to be a sensitive and specific agent for the detection of this neoplasm in rats. External gamma camera imaging (,23I) visualized tumors as small as 0.5 mm in diameter. Autoradiography (125I) indicated that IdUrd was incorporated into the DNA of neoplastic glia only. Since 123I emits γ-photons suitable for scintigraphy, [123I]IdUrd holds promise for the diagnosis of brain tumors in humans as well. Furthermore, since 123I and, 25I are Auger electron emitters that have demonstrated antineoplastic effects, direct administration of [123I]IdUrd or [125I]IdUrd into tumors may also have potential for the treatment of central nervous system malignancies.",
author = "Kassis, {Amin I.} and {Van den Abbeele}, {Annick D.} and Janina Baranowska-Kortylewicz and DeSisto, {William C.} and Aaronson, {Rebecca A.} and Adelstein, {S. James} and Wen, {Patrick Y.C.} and Lampson, {Lois A.} and Black, {Peter Mc L.}",
year = "1990",
month = "8",
day = "15",
language = "English (US)",
volume = "50",
pages = "5199--5203",
journal = "Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "16",

}

TY - JOUR

T1 - Specific Uptake of the Auger Electron-emitting Thymidine Analogue 5-[123I/125I]Iodo-2'-deoxyuridine in Rat Brain Tumors

T2 - Diagnostic and Therapeutic Implications in Humans

AU - Kassis, Amin I.

AU - Van den Abbeele, Annick D.

AU - Baranowska-Kortylewicz, Janina

AU - DeSisto, William C.

AU - Aaronson, Rebecca A.

AU - Adelstein, S. James

AU - Wen, Patrick Y.C.

AU - Lampson, Lois A.

AU - Black, Peter Mc L.

PY - 1990/8/15

Y1 - 1990/8/15

N2 - Glial neoplasms of the human central nervous system are malignancies that have defied treatment. Part of the problem lies in the limitations of current diagnostic techniques which are unable to identify small collections of neoplastic glia within normal parenchyma and in the difficulty of sterilizing these tumors because of limited selectivity of the cytotoxic agents available. The thymidine analogue 5-iodo-2'-deoxyuridine (IdUrd) radiolabeled with, 23I and 125I was injected directly into an intracerebral rat 9L gliosarcoma and found to be a sensitive and specific agent for the detection of this neoplasm in rats. External gamma camera imaging (,23I) visualized tumors as small as 0.5 mm in diameter. Autoradiography (125I) indicated that IdUrd was incorporated into the DNA of neoplastic glia only. Since 123I emits γ-photons suitable for scintigraphy, [123I]IdUrd holds promise for the diagnosis of brain tumors in humans as well. Furthermore, since 123I and, 25I are Auger electron emitters that have demonstrated antineoplastic effects, direct administration of [123I]IdUrd or [125I]IdUrd into tumors may also have potential for the treatment of central nervous system malignancies.

AB - Glial neoplasms of the human central nervous system are malignancies that have defied treatment. Part of the problem lies in the limitations of current diagnostic techniques which are unable to identify small collections of neoplastic glia within normal parenchyma and in the difficulty of sterilizing these tumors because of limited selectivity of the cytotoxic agents available. The thymidine analogue 5-iodo-2'-deoxyuridine (IdUrd) radiolabeled with, 23I and 125I was injected directly into an intracerebral rat 9L gliosarcoma and found to be a sensitive and specific agent for the detection of this neoplasm in rats. External gamma camera imaging (,23I) visualized tumors as small as 0.5 mm in diameter. Autoradiography (125I) indicated that IdUrd was incorporated into the DNA of neoplastic glia only. Since 123I emits γ-photons suitable for scintigraphy, [123I]IdUrd holds promise for the diagnosis of brain tumors in humans as well. Furthermore, since 123I and, 25I are Auger electron emitters that have demonstrated antineoplastic effects, direct administration of [123I]IdUrd or [125I]IdUrd into tumors may also have potential for the treatment of central nervous system malignancies.

UR - http://www.scopus.com/inward/record.url?scp=0025002682&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025002682&partnerID=8YFLogxK

M3 - Article

C2 - 2379179

AN - SCOPUS:0025002682

VL - 50

SP - 5199

EP - 5203

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 16

ER -