Spatially and temporally controlled hydrogels for tissue engineering

Jeroen Leijten, Jungmok Seo, Kan Yue, Grissel Trujillo-de Santiago, Ali Tamayol, Guillermo U. Ruiz-Esparza, Su Ryon Shin, Roholah Sharifi, Iman Noshadi, Mario Moisés Álvarez, Yu Shrike Zhang, Ali Khademhosseini

Research output: Contribution to journalReview article

46 Citations (Scopus)

Abstract

Recent years have seen tremendous advances in the field of hydrogel-based biomaterials. One of the most prominent revolutions in this field has been the integration of elements or techniques that enable spatial and temporal control over hydrogels’ properties and functions. Here, we critically review the emerging progress of spatiotemporal control over biomaterial properties towards the development of functional engineered tissue constructs. Specifically, we will highlight the main advances in the spatial control of biomaterials, such as surface modification, microfabrication, photo-patterning, and bioprinting, as well as advances in the temporal control of biomaterials, such as controlled release of molecules, photocleaving of proteins, and controlled hydrogel degradation. We believe that the development and integration of these techniques will drive the evolution of next-generation engineered tissues.

Original languageEnglish (US)
Pages (from-to)1-35
Number of pages35
JournalMaterials Science and Engineering R: Reports
Volume119
DOIs
StatePublished - Sep 2017

Fingerprint

Hydrogels
tissue engineering
Biocompatible Materials
Tissue engineering
Biomaterials
Hydrogel
Tissue
Microfabrication
Surface treatment
emerging
degradation
proteins
Proteins
Degradation
Molecules
molecules

Keywords

  • Biomaterials
  • Bioprinting
  • Cell-biomaterial interaction
  • Cellular microenvironments
  • Hydrogel
  • Microfabrication
  • Tissue engineering

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Leijten, J., Seo, J., Yue, K., Trujillo-de Santiago, G., Tamayol, A., Ruiz-Esparza, G. U., ... Khademhosseini, A. (2017). Spatially and temporally controlled hydrogels for tissue engineering. Materials Science and Engineering R: Reports, 119, 1-35. https://doi.org/10.1016/j.mser.2017.07.001

Spatially and temporally controlled hydrogels for tissue engineering. / Leijten, Jeroen; Seo, Jungmok; Yue, Kan; Trujillo-de Santiago, Grissel; Tamayol, Ali; Ruiz-Esparza, Guillermo U.; Shin, Su Ryon; Sharifi, Roholah; Noshadi, Iman; Álvarez, Mario Moisés; Zhang, Yu Shrike; Khademhosseini, Ali.

In: Materials Science and Engineering R: Reports, Vol. 119, 09.2017, p. 1-35.

Research output: Contribution to journalReview article

Leijten, J, Seo, J, Yue, K, Trujillo-de Santiago, G, Tamayol, A, Ruiz-Esparza, GU, Shin, SR, Sharifi, R, Noshadi, I, Álvarez, MM, Zhang, YS & Khademhosseini, A 2017, 'Spatially and temporally controlled hydrogels for tissue engineering', Materials Science and Engineering R: Reports, vol. 119, pp. 1-35. https://doi.org/10.1016/j.mser.2017.07.001
Leijten, Jeroen ; Seo, Jungmok ; Yue, Kan ; Trujillo-de Santiago, Grissel ; Tamayol, Ali ; Ruiz-Esparza, Guillermo U. ; Shin, Su Ryon ; Sharifi, Roholah ; Noshadi, Iman ; Álvarez, Mario Moisés ; Zhang, Yu Shrike ; Khademhosseini, Ali. / Spatially and temporally controlled hydrogels for tissue engineering. In: Materials Science and Engineering R: Reports. 2017 ; Vol. 119. pp. 1-35.
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