Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women

Barbara E. Merz-Demlow, Alison M. Duncan, Kerry E. Wangen, Xia Xu, Timothy P. Carr, William R. Phipps, Mindy S. Kurzer

Research output: Contribution to journalArticle

203 Citations (Scopus)

Abstract

Background: Soy consumption is known to reduce plasma total cholesterol and LDL cholesterol in hypercholesterolemic subjects, but the responsible soy components and the effects in normocholesterolemic subjects remain unclear. Objective: The effects of soy isoflavone consumption on plasma total cholesterol, HDL-cholesterol, LDL-cholesterol, triacylglycerol, apolipoprotein A-I, apolipoprotein B, and lipoprotein(a) concentrations and on LDL peak particle diameter were examined in normocholesterolemic, premenopausal women. Design: Thirteen healthy, normocholesterolemic, free- living, premenopausal female volunteers took part in this randomized, crossover-controlled trial. Each subject acted as her own control. Three soy isoflavone intakes (control: 10.0 ± 1.1; low: 64.7 ± 9.4; and high: 128.7 ± 15.7 mg/d), provided as soy protein isolate, were consumed for 3 menstrual cycles each. Total cholesterol, HDL cholesterol, LDL cholesterol, and triacylglycerol were measured over the menstrual cycle. Apolipoprotein A-I, apolipoprotein B, lipoprotein(a), and LDL peak particle diameter were evaluated in the midluteal phase. Results: Total cholesterol, HDL- cholesterol, and LDL-cholesterol concentrations changed significantly across menstrual cycle phases (P < 0.005). During specific phases of the cycle, the high-isoflavone diet lowered LDL cholesterol by 7.6-10.0% (P < 0.05), the ratio of total cholesterol to HDL cholesterol by 10.2% (P < 0.005), and the ratio of LDL to HDL cholesterol by 13.8% (P < 0.002). Conclusions: Isoflavones significantly improved the lipid profile across the menstrual cycle in normocholesterolemic, premenopausal women. Although of small magnitude, these effects could contribute to a lower risk of developing coronary heart disease in healthy people who consume soy over many years.

Original languageEnglish (US)
Pages (from-to)1462-1469
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume71
Issue number6
StatePublished - Jun 1 2000

Fingerprint

Isoflavones
isoflavones
low density lipoprotein cholesterol
menstrual cycle
high density lipoprotein cholesterol
blood lipids
LDL Cholesterol
HDL Cholesterol
Menstrual Cycle
Cholesterol
cholesterol
Lipids
apolipoprotein A-I
apolipoprotein B
Lipoprotein(a)
Apolipoprotein A-I
Apolipoproteins B
lipoproteins
triacylglycerols
Soybean Proteins

Keywords

  • Apoli poprotein A-I
  • Apolipoprotein B
  • Cholesterol
  • HDL
  • Isoflavone
  • LDL
  • Lipids
  • Lipoprotein(a)
  • Menstrual cycle
  • Phytoestrogen
  • Soy
  • Triacylglycerol
  • Women

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Merz-Demlow, B. E., Duncan, A. M., Wangen, K. E., Xu, X., Carr, T. P., Phipps, W. R., & Kurzer, M. S. (2000). Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women. American Journal of Clinical Nutrition, 71(6), 1462-1469.

Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women. / Merz-Demlow, Barbara E.; Duncan, Alison M.; Wangen, Kerry E.; Xu, Xia; Carr, Timothy P.; Phipps, William R.; Kurzer, Mindy S.

In: American Journal of Clinical Nutrition, Vol. 71, No. 6, 01.06.2000, p. 1462-1469.

Research output: Contribution to journalArticle

Merz-Demlow, BE, Duncan, AM, Wangen, KE, Xu, X, Carr, TP, Phipps, WR & Kurzer, MS 2000, 'Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women', American Journal of Clinical Nutrition, vol. 71, no. 6, pp. 1462-1469.
Merz-Demlow BE, Duncan AM, Wangen KE, Xu X, Carr TP, Phipps WR et al. Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women. American Journal of Clinical Nutrition. 2000 Jun 1;71(6):1462-1469.
Merz-Demlow, Barbara E. ; Duncan, Alison M. ; Wangen, Kerry E. ; Xu, Xia ; Carr, Timothy P. ; Phipps, William R. ; Kurzer, Mindy S. / Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women. In: American Journal of Clinical Nutrition. 2000 ; Vol. 71, No. 6. pp. 1462-1469.
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abstract = "Background: Soy consumption is known to reduce plasma total cholesterol and LDL cholesterol in hypercholesterolemic subjects, but the responsible soy components and the effects in normocholesterolemic subjects remain unclear. Objective: The effects of soy isoflavone consumption on plasma total cholesterol, HDL-cholesterol, LDL-cholesterol, triacylglycerol, apolipoprotein A-I, apolipoprotein B, and lipoprotein(a) concentrations and on LDL peak particle diameter were examined in normocholesterolemic, premenopausal women. Design: Thirteen healthy, normocholesterolemic, free- living, premenopausal female volunteers took part in this randomized, crossover-controlled trial. Each subject acted as her own control. Three soy isoflavone intakes (control: 10.0 ± 1.1; low: 64.7 ± 9.4; and high: 128.7 ± 15.7 mg/d), provided as soy protein isolate, were consumed for 3 menstrual cycles each. Total cholesterol, HDL cholesterol, LDL cholesterol, and triacylglycerol were measured over the menstrual cycle. Apolipoprotein A-I, apolipoprotein B, lipoprotein(a), and LDL peak particle diameter were evaluated in the midluteal phase. Results: Total cholesterol, HDL- cholesterol, and LDL-cholesterol concentrations changed significantly across menstrual cycle phases (P < 0.005). During specific phases of the cycle, the high-isoflavone diet lowered LDL cholesterol by 7.6-10.0{\%} (P < 0.05), the ratio of total cholesterol to HDL cholesterol by 10.2{\%} (P < 0.005), and the ratio of LDL to HDL cholesterol by 13.8{\%} (P < 0.002). Conclusions: Isoflavones significantly improved the lipid profile across the menstrual cycle in normocholesterolemic, premenopausal women. Although of small magnitude, these effects could contribute to a lower risk of developing coronary heart disease in healthy people who consume soy over many years.",
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AU - Carr, Timothy P.

AU - Phipps, William R.

AU - Kurzer, Mindy S.

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N2 - Background: Soy consumption is known to reduce plasma total cholesterol and LDL cholesterol in hypercholesterolemic subjects, but the responsible soy components and the effects in normocholesterolemic subjects remain unclear. Objective: The effects of soy isoflavone consumption on plasma total cholesterol, HDL-cholesterol, LDL-cholesterol, triacylglycerol, apolipoprotein A-I, apolipoprotein B, and lipoprotein(a) concentrations and on LDL peak particle diameter were examined in normocholesterolemic, premenopausal women. Design: Thirteen healthy, normocholesterolemic, free- living, premenopausal female volunteers took part in this randomized, crossover-controlled trial. Each subject acted as her own control. Three soy isoflavone intakes (control: 10.0 ± 1.1; low: 64.7 ± 9.4; and high: 128.7 ± 15.7 mg/d), provided as soy protein isolate, were consumed for 3 menstrual cycles each. Total cholesterol, HDL cholesterol, LDL cholesterol, and triacylglycerol were measured over the menstrual cycle. Apolipoprotein A-I, apolipoprotein B, lipoprotein(a), and LDL peak particle diameter were evaluated in the midluteal phase. Results: Total cholesterol, HDL- cholesterol, and LDL-cholesterol concentrations changed significantly across menstrual cycle phases (P < 0.005). During specific phases of the cycle, the high-isoflavone diet lowered LDL cholesterol by 7.6-10.0% (P < 0.05), the ratio of total cholesterol to HDL cholesterol by 10.2% (P < 0.005), and the ratio of LDL to HDL cholesterol by 13.8% (P < 0.002). Conclusions: Isoflavones significantly improved the lipid profile across the menstrual cycle in normocholesterolemic, premenopausal women. Although of small magnitude, these effects could contribute to a lower risk of developing coronary heart disease in healthy people who consume soy over many years.

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KW - Menstrual cycle

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KW - Women

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