Sox2/Oct4: A delicately balanced partnership in pluripotent stem cells and embryogenesis

A Angie Rizzino, Erin L. Wuebben

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Considerable progress has been made in understanding the roles of Sox2 and Oct4 in embryonic stem cells and mammalian embryogenesis. Specifically, significant progress has been made in answering three questions about the functions of Sox2 and Oct4, which are the focus of this review. 1) Are the first or second cell lineage decisions during embryogenesis controlled by Oct4 and/or Sox2? 2) Do the levels of Oct4 and Sox2 need to be maintained within narrow limits to promote normal development and to sustain the self-renewal of pluripotent stem cells? 3) Do Oct4 and Sox2 work closely together or is the primary role of Sox2 in pluripotent cells to ensure the expression of Oct4? Although significant progress has been made in answering these questions, additional studies are needed to resolve several important remaining issues. Nonetheless, the preponderance of the evidence suggests there is considerable crosstalk between Sox2 and Oct4, and further suggests Sox2 and Oct4 function as molecular rheostats and utilize negative feedback loops to carefully balance their expression and other critical genes during embryogenesis. This article is part of a Special Issue entitled: The Oct transcription factor family, edited by Dr. Dean Tantin.

Original languageEnglish (US)
Pages (from-to)780-791
Number of pages12
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume1859
Issue number6
DOIs
StatePublished - Jun 1 2016

Fingerprint

Pluripotent Stem Cells
Stem cells
Embryonic Development
Crosstalk
Transcription Factors
Genes
Cell Lineage
Embryonic Stem Cells
Feedback

Keywords

  • Embryogenesis
  • Embryonic stem cells
  • Negative feedback loop
  • Oct4
  • Pluripotent stem cells
  • Sox2

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Sox2/Oct4 : A delicately balanced partnership in pluripotent stem cells and embryogenesis. / Rizzino, A Angie; Wuebben, Erin L.

In: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, Vol. 1859, No. 6, 01.06.2016, p. 780-791.

Research output: Contribution to journalArticle

@article{c02cdba9085c4f2f83c22f01165679da,
title = "Sox2/Oct4: A delicately balanced partnership in pluripotent stem cells and embryogenesis",
abstract = "Considerable progress has been made in understanding the roles of Sox2 and Oct4 in embryonic stem cells and mammalian embryogenesis. Specifically, significant progress has been made in answering three questions about the functions of Sox2 and Oct4, which are the focus of this review. 1) Are the first or second cell lineage decisions during embryogenesis controlled by Oct4 and/or Sox2? 2) Do the levels of Oct4 and Sox2 need to be maintained within narrow limits to promote normal development and to sustain the self-renewal of pluripotent stem cells? 3) Do Oct4 and Sox2 work closely together or is the primary role of Sox2 in pluripotent cells to ensure the expression of Oct4? Although significant progress has been made in answering these questions, additional studies are needed to resolve several important remaining issues. Nonetheless, the preponderance of the evidence suggests there is considerable crosstalk between Sox2 and Oct4, and further suggests Sox2 and Oct4 function as molecular rheostats and utilize negative feedback loops to carefully balance their expression and other critical genes during embryogenesis. This article is part of a Special Issue entitled: The Oct transcription factor family, edited by Dr. Dean Tantin.",
keywords = "Embryogenesis, Embryonic stem cells, Negative feedback loop, Oct4, Pluripotent stem cells, Sox2",
author = "Rizzino, {A Angie} and Wuebben, {Erin L.}",
year = "2016",
month = "6",
day = "1",
doi = "10.1016/j.bbagrm.2016.03.006",
language = "English (US)",
volume = "1859",
pages = "780--791",
journal = "Biochimica et Biophysica Acta - Gene Regulatory Mechanisms",
issn = "1874-9399",
publisher = "Elsevier",
number = "6",

}

TY - JOUR

T1 - Sox2/Oct4

T2 - A delicately balanced partnership in pluripotent stem cells and embryogenesis

AU - Rizzino, A Angie

AU - Wuebben, Erin L.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Considerable progress has been made in understanding the roles of Sox2 and Oct4 in embryonic stem cells and mammalian embryogenesis. Specifically, significant progress has been made in answering three questions about the functions of Sox2 and Oct4, which are the focus of this review. 1) Are the first or second cell lineage decisions during embryogenesis controlled by Oct4 and/or Sox2? 2) Do the levels of Oct4 and Sox2 need to be maintained within narrow limits to promote normal development and to sustain the self-renewal of pluripotent stem cells? 3) Do Oct4 and Sox2 work closely together or is the primary role of Sox2 in pluripotent cells to ensure the expression of Oct4? Although significant progress has been made in answering these questions, additional studies are needed to resolve several important remaining issues. Nonetheless, the preponderance of the evidence suggests there is considerable crosstalk between Sox2 and Oct4, and further suggests Sox2 and Oct4 function as molecular rheostats and utilize negative feedback loops to carefully balance their expression and other critical genes during embryogenesis. This article is part of a Special Issue entitled: The Oct transcription factor family, edited by Dr. Dean Tantin.

AB - Considerable progress has been made in understanding the roles of Sox2 and Oct4 in embryonic stem cells and mammalian embryogenesis. Specifically, significant progress has been made in answering three questions about the functions of Sox2 and Oct4, which are the focus of this review. 1) Are the first or second cell lineage decisions during embryogenesis controlled by Oct4 and/or Sox2? 2) Do the levels of Oct4 and Sox2 need to be maintained within narrow limits to promote normal development and to sustain the self-renewal of pluripotent stem cells? 3) Do Oct4 and Sox2 work closely together or is the primary role of Sox2 in pluripotent cells to ensure the expression of Oct4? Although significant progress has been made in answering these questions, additional studies are needed to resolve several important remaining issues. Nonetheless, the preponderance of the evidence suggests there is considerable crosstalk between Sox2 and Oct4, and further suggests Sox2 and Oct4 function as molecular rheostats and utilize negative feedback loops to carefully balance their expression and other critical genes during embryogenesis. This article is part of a Special Issue entitled: The Oct transcription factor family, edited by Dr. Dean Tantin.

KW - Embryogenesis

KW - Embryonic stem cells

KW - Negative feedback loop

KW - Oct4

KW - Pluripotent stem cells

KW - Sox2

UR - http://www.scopus.com/inward/record.url?scp=84962486755&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962486755&partnerID=8YFLogxK

U2 - 10.1016/j.bbagrm.2016.03.006

DO - 10.1016/j.bbagrm.2016.03.006

M3 - Article

C2 - 26992828

AN - SCOPUS:84962486755

VL - 1859

SP - 780

EP - 791

JO - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

JF - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

SN - 1874-9399

IS - 6

ER -