Sorghum distillers dried grain lipid extract increases cholesterol excretion and decreases plasma and liver cholesterol concentration in hamsters

Jia Tse Hoi, Curtis L. Weller, Vicki L. Schlegel, Susan L. Cuppett, Ji Young Lee, Timothy P. Carr

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20 Scopus citations


Grain sorghum is a rich source of phytochemicals. In this study, male hamsters were fed AIN-93M diets supplemented with a hexane-extractable lipid fraction from sorghum distillers dried grains with solubles (DDGS). Diets contained 0.0%, 0.5%, 1.0%, and 5.0% (w/w) DDGS lipid extract. After 4 wk, the 5.0% DDGS lipids group had significantly lower plasma non-HDL cholesterol and liver esterified cholesterol concentration. Faecal neutral sterol (i.e., cholesterol) excretion was significantly higher in the 5.0% DDGS lipids group compared to the other treatments (66% higher compared to controls). Bile acid excretion was not affected by DDGS lipid intake. Faecal cholesterol excretion was negatively correlated with liver cholesterol concentration (r = -0.97, P = 0.026), and liver cholesterol concentration was directly correlated with plasma total cholesterol concentration (r = 0.96, P = 0.041). Thus, lipid extract of sorghum DDGS exhibited cholesterol-lowering properties due, at least in part, to increased cholesterol excretion from the body and could provide health benefits when incorporated into human diets.

Original languageEnglish (US)
Pages (from-to)381-386
Number of pages6
JournalJournal of Functional Foods
Issue number4
StatePublished - Oct 1 2009



  • Cholesterol
  • Hamsters
  • Lipid extract
  • Sorghum
  • Sterols

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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