Somatostatin‐like immunoreactivity in the midbrain of the cat

K. M. Spangler, Barbara J Morley

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Somatostatin (SS) immunoreactivity was localized in cat brain sections with an immunoperoxidase technique. Cell bodies in the midbrain containing SS immunoreactivity were found in the superficial and intermediate gray layers of the superior colliculus, the interpeduncular nucleus, the raphe, the inferior colliculus and nucleus of its brachium, the nucleus of the optic tract, and the lateral tegmental field. Additional positive neurons were seen in the parabigeminal nucleus and in the dorsal periaqueductal gray in kitten material. Immunoreactive fibers were observed in the periaqueductal gray and in the midbrain tegmentum, with particularly dense labeling just dorsal to the substantia nigra and in the parabrachial nuclei. This is the first report of the distribution of SS immunoreactivity in the midbrain of the cat. It is concluded that somatostatin has a distribution compatible with a role as a major neurotransmitter/neuromodulator within oertain midbrain nuclei, especially the interpeduncular nucleus and the superior colliculus.

Original languageEnglish (US)
Pages (from-to)87-97
Number of pages11
JournalJournal of Comparative Neurology
Volume260
Issue number1
DOIs
StatePublished - Jan 1 1987

Fingerprint

Mesencephalon
Somatostatin
Cats
Periaqueductal Gray
Superior Colliculi
Neurotransmitter Agents
Tegmentum Mesencephali
Inferior Colliculi
Substantia Nigra
Immunoenzyme Techniques
Arm
Neurons
somatostatin-like peptides
Brain
Interpeduncular Nucleus

Keywords

  • development
  • immunocytochemistry
  • interpeduncular nucleus
  • parabigeminal nucleus
  • superior colliculus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Somatostatin‐like immunoreactivity in the midbrain of the cat. / Spangler, K. M.; Morley, Barbara J.

In: Journal of Comparative Neurology, Vol. 260, No. 1, 01.01.1987, p. 87-97.

Research output: Contribution to journalArticle

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AB - Somatostatin (SS) immunoreactivity was localized in cat brain sections with an immunoperoxidase technique. Cell bodies in the midbrain containing SS immunoreactivity were found in the superficial and intermediate gray layers of the superior colliculus, the interpeduncular nucleus, the raphe, the inferior colliculus and nucleus of its brachium, the nucleus of the optic tract, and the lateral tegmental field. Additional positive neurons were seen in the parabigeminal nucleus and in the dorsal periaqueductal gray in kitten material. Immunoreactive fibers were observed in the periaqueductal gray and in the midbrain tegmentum, with particularly dense labeling just dorsal to the substantia nigra and in the parabrachial nuclei. This is the first report of the distribution of SS immunoreactivity in the midbrain of the cat. It is concluded that somatostatin has a distribution compatible with a role as a major neurotransmitter/neuromodulator within oertain midbrain nuclei, especially the interpeduncular nucleus and the superior colliculus.

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