Solid-State NMR and the Crystallization of Aspartic and Glutamic Acids

Yali Wang, Daniel Wilson, Gerard S. Harbison

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We used high-resolution solid-state 13C NMR, with cross-polarization and magic-angle spinning, to study chirality in the crystallization of aspartic acid. We show that, contrary to a recent report, dl-aspartic acid crystallizes over most of its temperature range as racemic crystals rather than a conglomerate of enantiomeric crystals, regardless of whether the solution was prepared by solution of the racemate or by mixing solutions of the pure enantiomers. Over virtually the entire solution temperature range at 1 bar pressure, racemic crystals of aspartic acid are thermodynamically stable, whereas the conglomerate is metastable. In contrast, in agreement with the literature, glutamic acid crystallizes as a conglomerate under thermodynamic conditions. Solid-state NMR results are confirmed by powder X-ray diffraction.

Original languageEnglish (US)
Pages (from-to)625-631
Number of pages7
JournalCrystal Growth and Design
Volume16
Issue number2
DOIs
StatePublished - Feb 3 2016

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Glutamates
aspartic acid
glutamic acid
Crystallization
Nuclear magnetic resonance
Aspartic Acid
crystallization
solid state
nuclear magnetic resonance
Acids
Crystals
crystals
Magic angle spinning
Enantiomers
Chirality
cross polarization
enantiomers
chirality
X ray powder diffraction
metal spinning

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Solid-State NMR and the Crystallization of Aspartic and Glutamic Acids. / Wang, Yali; Wilson, Daniel; Harbison, Gerard S.

In: Crystal Growth and Design, Vol. 16, No. 2, 03.02.2016, p. 625-631.

Research output: Contribution to journalArticle

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