Solid-phase synthesis of alkyl aryl ethers via the ullmann condensation

Xiao Yi Xiao, Rongshi Li, David Hurst, Hui Zhuang, Shuhao Shi, Anthony W. Czarnik, Albert J. Robichaud, Dean A. Wacker, David W. Robertson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Alkyl aryl ether formation is a frequently employed reaction in organic synthesis. Ullmann condensation is an alternative method to the widely used Mitsunobu reaction and is very useful in situations where application of the Mitsunobu reaction is limited. By application of this reaction to solid-phase synthesis of a series of alkyl aryl ethers, reaction conditions (catalyst, solvent, temperature, time, etc.) for a sterically hindered class of alcohols were investigated and optimized. A range of aryl halides was used to explore the scope of the reaction in solid phase.

Original languageEnglish (US)
Pages (from-to)536-539
Number of pages4
JournalJournal of Combinatorial Chemistry
Volume4
Issue number5
DOIs
StatePublished - Sep 1 2002

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Synthetic Chemistry Techniques
Solid-Phase Synthesis Techniques
Ethers
Condensation
Ether
Alcohols
Synthesis
Temperature
Catalysts
Alcohol
Catalyst
Series
Alternatives
Range of data

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Xiao, X. Y., Li, R., Hurst, D., Zhuang, H., Shi, S., Czarnik, A. W., ... Robertson, D. W. (2002). Solid-phase synthesis of alkyl aryl ethers via the ullmann condensation. Journal of Combinatorial Chemistry, 4(5), 536-539. https://doi.org/10.1021/cc020035q

Solid-phase synthesis of alkyl aryl ethers via the ullmann condensation. / Xiao, Xiao Yi; Li, Rongshi; Hurst, David; Zhuang, Hui; Shi, Shuhao; Czarnik, Anthony W.; Robichaud, Albert J.; Wacker, Dean A.; Robertson, David W.

In: Journal of Combinatorial Chemistry, Vol. 4, No. 5, 01.09.2002, p. 536-539.

Research output: Contribution to journalArticle

Xiao, XY, Li, R, Hurst, D, Zhuang, H, Shi, S, Czarnik, AW, Robichaud, AJ, Wacker, DA & Robertson, DW 2002, 'Solid-phase synthesis of alkyl aryl ethers via the ullmann condensation', Journal of Combinatorial Chemistry, vol. 4, no. 5, pp. 536-539. https://doi.org/10.1021/cc020035q
Xiao, Xiao Yi ; Li, Rongshi ; Hurst, David ; Zhuang, Hui ; Shi, Shuhao ; Czarnik, Anthony W. ; Robichaud, Albert J. ; Wacker, Dean A. ; Robertson, David W. / Solid-phase synthesis of alkyl aryl ethers via the ullmann condensation. In: Journal of Combinatorial Chemistry. 2002 ; Vol. 4, No. 5. pp. 536-539.
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