Soil-mediated prion transmission: Is local soil-type a key determinant of prion disease incidence?

Samuel E. Saunders, Jason C. Bartz, Shannon L Bartelt-Hunt

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Prion diseases, including chronic wasting disease (CWD) and scrapie, can be transmitted via indirect environmental routes. Animals habitually ingest soil, and results from laboratory experiments demonstrate prions can bind to a wide range of soils and soil minerals, retain the ability to replicate, and remain infectious, indicating soil could serve as a reservoir for natural prion transmission and a potential prion exposure route for humans. Preliminary epidemiological modeling suggests soil texture may influence the incidence of prion disease. These results are supported by experimental work demonstrating variance in prion interactions with soil, including variance in prion soil adsorption and soil-bound prion replication with respect to soil type. Thus, local soil type may be a key determinant of prion incidence. Further experimental and epidemiological work is required to fully elucidate the dynamics of soil-mediated prion transmission, an effort that should lead to effective disease management and mitigation strategies.

Original languageEnglish (US)
Pages (from-to)661-667
Number of pages7
JournalChemosphere
Volume87
Issue number7
DOIs
StatePublished - May 1 2012

Fingerprint

prion disease
disease incidence
Prion Diseases
Prions
soil type
Soil
Soils
Incidence
soil
scrapie
chronic wasting disease
Chronic Wasting Disease
soil texture
Scrapie
mitigation
Disease Management
adsorption
Adsorption
Minerals

Keywords

  • BSE
  • CJD
  • Fate
  • N-terminus
  • PrP protein
  • Transmissible spongiform encephalopathy

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Soil-mediated prion transmission : Is local soil-type a key determinant of prion disease incidence? / Saunders, Samuel E.; Bartz, Jason C.; Bartelt-Hunt, Shannon L.

In: Chemosphere, Vol. 87, No. 7, 01.05.2012, p. 661-667.

Research output: Contribution to journalReview article

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N2 - Prion diseases, including chronic wasting disease (CWD) and scrapie, can be transmitted via indirect environmental routes. Animals habitually ingest soil, and results from laboratory experiments demonstrate prions can bind to a wide range of soils and soil minerals, retain the ability to replicate, and remain infectious, indicating soil could serve as a reservoir for natural prion transmission and a potential prion exposure route for humans. Preliminary epidemiological modeling suggests soil texture may influence the incidence of prion disease. These results are supported by experimental work demonstrating variance in prion interactions with soil, including variance in prion soil adsorption and soil-bound prion replication with respect to soil type. Thus, local soil type may be a key determinant of prion incidence. Further experimental and epidemiological work is required to fully elucidate the dynamics of soil-mediated prion transmission, an effort that should lead to effective disease management and mitigation strategies.

AB - Prion diseases, including chronic wasting disease (CWD) and scrapie, can be transmitted via indirect environmental routes. Animals habitually ingest soil, and results from laboratory experiments demonstrate prions can bind to a wide range of soils and soil minerals, retain the ability to replicate, and remain infectious, indicating soil could serve as a reservoir for natural prion transmission and a potential prion exposure route for humans. Preliminary epidemiological modeling suggests soil texture may influence the incidence of prion disease. These results are supported by experimental work demonstrating variance in prion interactions with soil, including variance in prion soil adsorption and soil-bound prion replication with respect to soil type. Thus, local soil type may be a key determinant of prion incidence. Further experimental and epidemiological work is required to fully elucidate the dynamics of soil-mediated prion transmission, an effort that should lead to effective disease management and mitigation strategies.

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